The present invention is directed to a system and method for producing an organic compound using fermentation wherein multiple components of the system are recycled within the system. The system and method allow for extraction of a high concentration of the organic compound from the fermentation broth in a continuous system that allows recycling of the biomass, aqueous fermentation broth and extraction solvents. The system and method are particularly well adapted for producing and extracting ethanol.

The disclosure relates to systems, devices and methods for at least one of cell and gene therapy manufacture. In some embodiments, a cell processing unit is provided and comprises a housing defining an enclosure into which a cell processing platform can be mounted, a platform mounting bracket within the housing and configured and arranged to receive and retain a cell processing platform, a drive apparatus configured and arranged to operatively engage and act upon a cell processing platform so as to move same with respect to the platform mounting bracket, and an actuator configured and arranged to exert a force on a container mounted into the cell processing platform so as to expel a contents from the container.

The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for controlling a flow of fluid in a fluid line connected to said container; a pump device (8) for generating a conveyor pressure of the fluid in the fluid line; a control device (10) which can be connected to the valve (6) and/or the pump device (8) in order to control the valve (6) and/or pump device (8); and a frame (2) which supports said container receiving portion (4), valve (6), pump device (8) and control device (10).

A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

The present disclosure provides an automatic microfluidic system for rapid personalized drug screening including a microfluidic chip. The microfluidic chip includes a fluid storage unit, a fluid driving unit, a reaction unit and a plurality of valve units. The fluid driving unit includes two mixing pumps. Each of the mixing pumps includes two pneumatic micro-pumps, a mixing chamber and a blocking structure. The blocking structure is disposed in the mixing chamber and is connected between the two pneumatic micro-pumps. When the two pneumatic micro-pumps are started alternately, the blocking structure is deflected alone with the operation of the two pneumatic micro-pumps.

Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.

Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.

Disclosed is an ultrahigh-pressure homogenizing integrated device and a cell disruptor. The ultrahigh-pressure homogenizing integrated device includes a long oil cylinder, a main connecting sleeve, a high-pressure cylinder homogenizing main body, an auxiliary connecting sleeve and a short oil cylinder, which are sequentially and coaxially arranged. An upper part of the high-pressure cylinder homogenizing main body is provided with a feeding hole communicated with a high-pressure cavity; and the feeding hole is connected with an integrated feeding device. A pressurizing plunger rod in the high-pressure cavity of the high-pressure cylinder homogenizing main body is connected with a piston rod of the long oil cylinder; and a homogenizing valve arranged in the inner cavity, which is communicated with the high-pressure cavity, of the high-pressure cylinder homogenizing main body, is connected with an ejector rod of the short oil cylinder.

The invention generally relates to a microfluidic platforms or chips for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.

The present application provides a reactor with an inclined bottom gas-inlet for aerobic fermentation. A fermenter is provided with a circular inner tank, end covers and a jacket. An airtight fermentation space is formed in the fermenter by the inner tank, an upper end cover and a lower end cover. A feed opening and an exhaust outlet are arranged at an upper part of the fermenter, and a discharge opening is arranged at a lower part of the lower end cover of the fermenter. An energy-saving stirrer is mounted in the fermenter. A plurality of air chambers are arranged at an external wall at the bottom of the inner tank of the fermenter and are within the jacket. A plurality of aeration nozzles are defined on an inner side of each air chamber, and the aeration nozzles are disposed next to the inner tank.