An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.

An apparatus and method for the optimization of growth processes of photosynthetic organisms by means of the use of an optical system of artificial lighting are provided. An apparatus for culture of photosynthetic microorganisms includes at least one first panel containing the photosynthetic microorganisms and at least one device for artificial lighting of the photosynthetic microorganisms. The at least one device for artificial lighting is an optical device and comprises an optical guide, a plurality of LEDs, and a regulation and control panel of the at least one device for artificial lighting. The regulation and control panel-is configured to vary both a spectrum, between 200 and 900 nm in order to optimize quality of light emitted, and light intensity, between 1% and 100% in order to obtain emission uniformity, through the optical guide.

A culture plate including: an array of light sources formed inside and on top of a semiconductor substrate; a transparent planarization layer coating the array of light sources; and an array of wells formed on said layer, each light source being located vertically in line with a well.

The invention relates to a bioprocess container (10) having an optical measuring device (100) for non-invasive spectroscopic measurement comprising: a container housing (12), a port housing (102), which is connected to the container housing (12) and is sealed off with respect to the interior (18) of the container housing (12); at least one radiation-emitting element (124), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12); at least one radiation-receiving element (126), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (124); and at least one measuring insert (122), which holds and supports the at least one radiation-emitting element (124) and/or the at least one radiation-receiving element (126).

The invention relates to a lamp module (10) which is designed to be used as an immersion radiator in photochemical reactors. The lamp module has a support body (3) with at least one light-emitting diode (LED) (1), a head part (12) for electrically connecting the at least one LED (1) and for mounting the support body (3), and an immersion tube (11) that delimits an area (19) in which the support body (3) is arranged together with the at least one LED (1). The area (19) delimited by the immersion tube (11) is filled with an electrically non-conductive liquid (100), which is transparent to the wavelengths of the radiation emitted by the LEDs (1) of the lamp module (10), such that the at least one LED (1) is completely immersed into the non-conductive liquid (100), wherein the head part (12) has connection lines (18, 18) which communicate with the area (19) for supplying and discharging the non-conductive liquid (100), and the support body (3) is designed as a heat sink which delimits at least one internal fluid path as a supply section (4) for the non-conductive liquid (100). The supply section (4) is connected to one of the connection lines (18, 18′) via the head part (12) and opens into the area (19) on the support body (3) side facing away from the head part (12). The invention additionally relates to a photoreactor which is equipped with a corresponding lamp module.

The invention relate to a light and temperature device for increasing and optimizing the production of biomass in bioreactors, said device comprising an LED light arrangement with LED light arrays and cooling fins facing away from the LED light arrays. The light and temperature device further comprising at least one fastening means for removably fastening the light arrangement to a transparent incubation vessel the LED light arrangement being oriented in relation to the incubation vessel such that light radiation emitted by the LED light arrangement in directed towards the incubation vessel.

A method executed by a bioreactor system to cultivate a microalgae comprising a photoreceptor sensitive to a region of a visible spectrum under an autotrophic condition and a fermentation condition is described. A first process incubates the microalgae under the autotrophic condition and the fermentation condition simultaneously to allow the microalgae to grow and then removes the fermentation condition halfway through the process. A second process incubates the microalgae under the autotrophic condition and the fermentation condition simultaneously to allow the microalgae to grow. Both processes generate compounds, or functional proteins.

Provided are systems and methods for spatially and temporally controlling light with an illumination device comprising a light source operably connected to a circuit board, one or more light guide plates, one or more optical masks, a controller, and a computer readable medium, comprising instructions that, when executed by the controller, cause the controller to: illuminate a cell or a substrate with light from the light source, and spatially and temporally control illumination of light to the cell or the substrate with one or more illumination parameters, wherein the one or more light guide plates provides uniform illumination of the light. Also provided herein are methods of screening using the system and/or device of the present disclosure.

The invention relates to a process and equipment for cultivating and producing a biomass from microalgae, primarily plankton. A microalgal biomass is cultivated in a single bioreactor chamber in the shape of a vertically oriented parallelepiped. The culture mixture is illuminated by artificial light sources mounted on the inner side of one of the broad walls of the bioreactor chamber in horizontal rows throughout the height of the bioreactor chamber. The culture mixture is illuminated cyclically. Spray heads are mounted on the inner side of the opposite wall of the bioreactor chamber so that 4 spray heads are arranged symmetrically around each artificial light source. The pH value of the culture mixture is maintained in a range of 8.5-9.5 by the addition thereto of a lactic acid bacteria-containing solution at the beginning of each light cycle in an amount of 1-3 ml per litre of culture mixture, said solution having a pH value selected in a range of 4.0-5.0.

Disclosed is a mass-cultivation system for microalgae, including a reactor that contains a cultivation liquid in the interior thereof, wherein the liquid includes functional particles. According to the mass-cultivation system for microalgae according to the present invention, because various functions that are necessary for cultivation of microalgae may be uniformly distributed in a cultivation liquid by allowing functional particles having various functions to flow in the cultivation liquid, a suitable environment may be created based on the cultivation of a large amount of microalgae and the growth of microalgae so that a high efficiency cultivation system may be realized while the problems of mass-cultivation of an existing cultivation system may be solved.