A microalgae culture broth producing system includes a device for culture broth sterilization using a micro bubble generator, an air compression and pressure equalization device for the injection of carbon dioxide and oxygen in the atmosphere into the culture broth. The system also includes an air chilling device to maintain suitable culture broth temperature when water temperature is too high, an automatic carbon dioxide supply device to promote photosynthesis, and a sealed vertical photobioreactor to block out pollutants and increase dissolved carbon dioxide and oxygen concentration. The system further includes a high-efficiency harvesting device using hollow fiber membranes, and a hot air drying device using the waste heat generated by air compression.

Embodiments disclosed herein relate to novel flasks, methods and systems employing said novel flasks, and sensors for use within said flasks and systems. In some embodiments, flasks and systems described herein are used to culture cells and/or detect changes in pH levels or dissolved oxygen and/or carbon dioxide levels in a cell culture sample resulting from the growth of living cells contained within a reaction vessel such as a flask. The devices may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells.

Systems and methods for verifying physical measurements taken for bioreactors are disclosed. Physical measurements may be taken using one or more sensors coupled to a bioreactor. The sensors may measure properties of the bioreactor or properties of materials within the bioreactor. Verifying the physical measurements may be implemented to enable proof of physical work being completed by the bioreactor.

Disclosed is a cell culture incubator system having a sensor strip configured to be placed within a reaction vessel (e.g., incubator vessel) so as to position the sensor within media covering the cells. A reader is placed outside but adjacent the vessel to read the sensor so as to detect changes in dissolved O.sub.2 and pH. The system is used to determine if the incubator environment has too much CO.sub.2 and is therefore trending towards hypoxia and/or acidity, or has too much dissolved O.sub.2 and is therefore trending toward oxygen toxicity via the cell nutrient media. In some embodiments, the system includes a rocker unit configured to rock the reaction vessel to enhance cell growth. In some embodiments, the system includes a gas circulation system to adjust the CO.sub.2 and dissolved O.sub.2 levels in the reaction vessel.

A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.

The method comprises an automated removal of cells and/or cell colonies from a cell culture whilst executing a first detection step for selecting cells and/or cell colonies with reference to corporeal and/or physical parameters and detecting position data and storing the detected position data of the selected cells and/or cell colonies in a position database. In order to be able to select special cells and/or cell colonies having special properties from the detected cells and/or cell colonies, at least one second detection step for detecting at least one further parameter of the cells and/or cell colonies is then executed, comparative data from the data of the first and second detection step are created, cells and/or cell colonies are selected with reference to the comparative data and the position data from the position database are transferred to a harvesting unit.

A photobioreactor for culturing light-sensitive microbes is provided, the reactor comprising a body comprising at least one floor panel and at least one wall extending upwardly around the periphery of the floor panel to define a body, wherein the at least one floor panel comprises at least one graded segment so as to define a trough along the bottom of the body towards which debris within the body flows, at least one illumination panel within the body so that there is free flow of liquid along the sides and floor panel of the body, at least one gas inlet within the trough in the floor panel, for providing an upward stream of gas into the body so as to generate air lift of the light sensitive microbes within the body. Also provided is a method for growing light-sensitive microbes.

A fine particle measurement device includes a support stand (20) that has a groove (F) extending in a predetermined direction and is configured to support in the groove an observation container (10), which has an elongate shape and accommodates a liquid sample containing a fine particle therein such that an extending direction of the groove (F) coincides with a longitudinal direction of the observation container (10); and an imaging unit (40) that is configured to capture an image of the fine particle in the observation container (10) at a position where the support stand is out of a field of view, the observation container (10) being supported by the support stand (20).

A multi-sensor component for the installation of at least two sensors at an individual port of a container for culturing biological material is provided. The multi-sensor component has a housing that can be introduced by a front housing segment into an uptake opening extending through the port of the container so that the front housing segment is facing the inside of the container. The multi-sensor component has a first sensor unit or a mount for a first sensor unit arranged on the front housing segment and has a second sensor unit or a mount for a second sensor unit arranged on the front housing segment.

A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.