A system for producing a hydrophobic chemical includes circulating biofilm bioreactors for synthesizing the hydrophobic products and continuous extraction into an organic solvent phase. Various configurations can be employed for assembling the bioreactors into a production module. Extraction operations can be conducted in one or more extraction vessels. In some cases, product and solvent are separated using membrane separation techniques, with solvent being rerouted to the extraction vessel(s). Methods for the biotransformation of feedstocks into chemical products also are described.

Provided is an anaerobic digestion process monitoring system for predicting a biogas production amount with high accuracy even when the activity of anaerobic microorganisms in a digestion tank changes. The anaerobic digestion process monitoring system includes: a first sensor which measures a feeding amount of organic waste into a digestion tank and outputs a measurement result as load data; a second sensor which measures a property of a fermented liquid inside the digestion tank and outputs a measurement result as fermented liquid property data; a preprocessing unit which calculates estimate activity index data indicating an anaerobic microorganism activity level from load data and fermented liquid property data, using a first estimation model; and a gas production amount prediction unit which calculates a biogas production amount prediction value from load data, fermented liquid property data, and estimate activity index data, using a second estimation model.

The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.

Provided is an anaerobic digestion process monitoring system for predicting a biogas production amount with high accuracy even when the activity of anaerobic microorganisms in a digestion tank changes. The anaerobic digestion process monitoring system includes: a first sensor which measures a feeding amount of organic waste into a digestion tank and outputs a measurement result as load data; a second sensor which measures a property of a fermented liquid inside the digestion tank and outputs a measurement result as fermented liquid property data; a preprocessing unit which calculates estimate activity index data indicating an anaerobic microorganism activity level from load data and fermented liquid property data, using a first estimation model; and a gas production amount prediction unit which calculates a biogas production amount prediction value from load data, fermented liquid property data, and estimate activity index data, using a second estimation model.

The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.

[Problem] To provide a system for inference of a measurement target dynamic state, the system being capable of providing not only information as to whether a culture solution is aerobic or anaerobic, but also data for determining a culture operation and for optimizing various conditions of the culture solution. [Solution] A system for inference of a measurement target dynamic state, comprising: a reference electrode; a first working electrode; a second working electrode of which at least the material or surface treatment is different from the first working electrode; a third working electrode of which at least the material or surface treatment is different from the first working electrode and the second working electrode; and an information storage unit which receives first potential information relating to the redox potential between the reference electrode and the first working electrode, second potential information relating to the redox potential between the reference electrode and the second working electrode, and third potential information relating to the redox potential between the reference electrode and the third working electrode, and stores information including the first potential information, the second potential information, and the third potential information.