A device assembly including a single-use device for sensing or influencing a parameter of a running bioprocess. The single-use device is configured to have at least two different defined functional states, a first functional state being an inactive delivery state in which the single-use device is sterile and inoperable according to its intended use, and a second functional state being an active use state in which the single-use device is operable according to its intended use. The device assembly further includes a signalling element for indicating a current functional state of the single-use device to a user. Each functional state is associated with a distinct signal. The device assembly is configured such that a transfer from the first functional state to any other functional state of the single-use device is irreversible and/or permanently prevents the signalling element from indicating the signal associated with the first functional state.

A bioreactor exhaust system includes an exhaust tube, a shut off valve, and a vessel. The exhaust tube includes a level sensor. The vessel includes a sterilant. The shut off valve is responsive to the sterilant reaching the level sensor.

A bioreactor exhaust system includes an exhaust tube, a shut off valve, and a vessel. The exhaust tube includes a level sensor. The vessel includes a sterilant. The shut off valve is responsive to the sterilant reaching the level sensor.

Disclosed is a system for cultivating and harvesting a cyanobacterial biomass. The system comprises at least one vessel that, when in operation, grows the cyanobacterial biomass in a nutrient growth media under regulated growth conditions and a base unit configured to receive the at least one vessel. The system also comprises at least one light source and a cultivation air pump that, when in operation, supplies light, heat and air to the at least one vessel. Notably, the cultivation air pump supplied air via a one-way air valve in the at least one vessel. The system also comprises at least one photodiode that, when in operation, measure a cyanobacterial biomass concentration in the at least one vessel. Disclosed also is a method for cultivating and harvesting a cyanobacterial biomass.

The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retenate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.

A gas concentration regulator for use in culture of anaerobic bacteria, including: (a) dehydroascorbic acid; (c) a transition metal catalyst; (d) activated carbon; (e) at least one selected from the group consisting of an alkali metal carbonate, an alkali metal hydroxide, and an alkaline earth metal hydroxide; and (f) water.

A system for simultaneously measuring refractive index and turbidity of a liquid sample is provided. The system comprises a coherent light source configured to generate a coherent light signal, an optical structure being in contact with the liquid sample, the optical structure is configured to transmit the coherent light signal to the liquid sample and further to receive a light signal from the liquid sample in response to the coherent light signal, and a detector configured to receive the light signal and further to measure refractive index and turbidity of the liquid sample simultaneously from the light signal.

The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.

The present invention relates to the expanding field of research relating to long-term living of humans in space environment, particularly to systems and processes for the production of high-quality, high-protein nutritional products, particularly for the production of cultured meat products in space.

The invention relates to a cultivation system comprising a cultivation container, in particular a hand-held cultivation container, preferably in the form of a shake flask, for holding a culture medium, the cultivation container having a neck and an opening extending through the neck, and a container attachment that can be placed on the neck of the cultivation container so as to close the opening of the cultivation container, in particular in a sterile manner, the container attachment having an inner side and an outer side, the inner side facing the interior of the cultivation container and the outer side facing the exterior of the cultivation container when the container attachment is placed on the neck of the cultivation container, wherein the container attachment comprises at least one sensor unit or a port for installing a sensor unit, the sensor unit being at least partially arranged or arrangeable on the inner side of the container attachment, to provide for parameter measurement in the interior of the cultivation container, and/or wherein the container attachment comprises at least one dispensing unit or a port for installing a dispensing unit, the dispensing unit being at least partially arranged or arrangeable on the inner side of the container attachment, to enable liquid to be dispensed into the interior of the cultivation container.