A data management system according to an embodiment includes a first storage control unit, a second storage control unit, and a third storage control unit. The first storage control unit controls storing, in a memory, one or more culture conditions indicating conditions for culturing a cell. The second storage control unit controls storing, in the memory, one or more pieces of measurement data for the cell cultured based on any one of the culture conditions. The third storage control unit controls storing, in the memory, one or more pieces of the measurement data designated among the pieces of the measurement data and one or more of the culture conditions designated among the culture conditions, in association with each other.

Techniques for predicting an amount of at least one biomaterial produced or consumed by a biological system in a bioreactor are provided. Process conditions and metabolite concentrations are measured for the biological system as a function of time. Metabolic rates for the biological system, including specific consumption rates of metabolites and specific production rates of metabolites are determined. The process conditions and the metabolic rates are provided to a hybrid system model configured to predict production of the biomaterial. The hybrid system model includes a kinetic growth model configured to estimate cell growth as a function of time and a metabolic condition model based on metabolite specific consumption or secretion rates and select process conditions, wherein the metabolic condition model is configured to classify the biological system into a metabolic state. An amount of the biomaterial based on the hybrid system model is predicted.

Methods for determining ethylene concentration in an ethylene oligomerization reactor using an ultrasonic flow meter are described, and these methods are integrated into ethylene oligomerization processes and related oligomerization reactor systems.

Methods for monitoring, controlling and simulating a bioprocess comprising a cell culture in a bioreactor are provided. The methods comprise obtaining values of one or more process conditions for the bioprocess at one or more maturities, and determining the specific transport rates of one or more metabolites in the cell culture using the values obtained as input to a machine learning model trained to predict the specific transport rates of the one or more metabolites at a latest maturity of the one or more maturities or a later maturity based at least in part on the values of one or more process conditions for the bioprocess at the one or more preceding maturities. The methods further comprise predicting one or more features of the bioprocess based at least in part on the determined specific transport rates. Systems, computer readable media and methods for providing tools to implement such methods are also provided.

The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.

An interconnected photosynthesis matrix and bio-energy production system. More specifically, a self-sustaining bio-system that uses the bio-energy production system, which comprises a selection process, an extraction process, and a transfer process, to create an energy enhanced organism and then uses the energy from the energy enhanced organisms for human use and/or for the second portion of the system, the photosynthesis matrix, where photosynthesis takes place. The energy is extracted from the energy enhanced organism by creating an energy rich homogenate, and then the energy is transferred to the grid, to an energy storage device, or to the photosynthesis matrix. The photosynthesis matrix consumes carbon dioxide and reduces carbon dioxide concentration while producing glucose, which it then provides to the bio-energy production system. The two systems work together in a feedback loop to allow continuous chemical reactions.

The present invention relates to a low specific gravity microcarrier-based cell culture apparatus and a method of monitoring cell culture using the same. More particularly, the present invention relates to four-dimensional cell culture that enables monitoring of the growth state of cells by reflecting a time factor in three-dimensional cell culture and is capable of stable cell expansion culture by minimizing change in cell characteristics.

The present invention is a manufacturing method for producing fermentation products using a fermentation vessel, including steps of: preparing a fermentation vessel and a sensor, introducing liquid into the fermentation vessel, and operating the fermentation vessel in which properties of liquid in the fermentation vessel are measured to adjust operating conditions; wherein the sensor device has a sensor for measuring liquid properties and a sensor cover body; a bottom permeable portion for passing liquid and crystals in the liquid is disposed on the bottom surface of the cover body, and a top permeable portion for passing liquid and crystals in the liquid is disposed on the top surface of the cover body; micropores are respectively formed in the bottom permeable portion and the top permeable portion; and micropores disposed in the top permeable portion are the same or larger than micropores disposed in the top permeable portion.

A compound algae culture apparatus is provided, which includes a photobioreactor module, a growth regulating module, a circulation transfer module, and a circulation pipeline module. The photobioreactor module includes at least one photobioreactor unit, and the growth regulating module includes at least one growth tank unit. The photobioreactor unit includes a light-transmitting coiled pipe. The growth tank unit has a tank body, and a plurality of partitions are disposed in the tank body to divide an inside of the tank body for formation of a curved flow channel A culture fluid for culturing algae passes through the photobioreactor unit and enters the growth tank unit. A volume of the growth tank unit is larger than a volume of the photobioreactor unit, and a residence time of the culture fluid in the growth tank unit is greater than a residence time of the culture fluid in the photobioreactor unit.

A methane generating device includes: a culture tank in which methane generating bacteria are cultured with a culture liquid; a gas feed device that feeds carbon dioxide and hydrogen gas required by the methane generating bacteria to the culture tank; and a generated gas extraction device that extracts methane generated by the methane generating bacteria.