Disclosed is a bioreactor including a rotation device that rotates a reaction container while a reference direction is taken as an axial direction thereof, and an angle adjusting device coupled to the rotation device to adjust an angle defined by the reference direction, which is dependent on an arrangement posture of the rotation device, with respect to a ground surface, by changing the arrangement posture of the rotation device.

An orbital shaker device (1) for biotechnological and/or biomedical applications comprises a frame (10), a platform (15) for receiving biotechnological and/or biomedical containers (50), eccentric couplings (13, 14) for allowing an orbital movement of the platform (15) relative to the frame (10), counterweight units (17, 18) for balancing the orbital movement, and at least one motor (19) for driving the eccentric couplings (13, 14). The device comprises two eccentric couplings (13, 14) arranged near respective opposite edges (27, 28) of the platform (15), while each counterweight unit (17, 18) is arranged approximately in the plane of the combined center of gravity of the platform (15) and the containers (50). Furthermore, both eccentric couplings (13, 14) are driven by the motor (19) or motors, either directly or indirectly. In this way, an optimal vibration compensation is achieved while allowing an imaging unit (40) to be mounted underneath the platform (15).

In one example in accordance with the present disclosure, a cell analysis system is described. The cell analysis system includes at least one cell analysis device. Each cell analysis device includes a channel to serially feed individual cells from a volume of cells into a lysing chamber. The cell analysis device also includes at least one feedback-controlled lysing element in the lysing chamber to agitate a cell. The cell analysis system also includes a controller to analyze the cell. The controller includes a lysate analyzer to analyze properties of the lysate and a rupture analyzer to analyze parameters of an agitation when a cell membrane ruptures.

A method and an apparatus for producing biogas from organic matter including a container (1) which is charged with fermentation substrate by a delivery system (13). At least one stirring mechanism (2) is arranged in the container. The feedback value of at least one measurable variable is detected and transmitted to a control unit (4). A reference variable is also provided to the control unit. The control unit calculates the deviation of the feedback value from the reference value, and actuating variables which modify the power input of the stirring mechanism and/or the composition of the container contents and/or the flow behavior of the container contents are adjusted as a function of the deviation.

An improved cell culture monitoring system and method that detects cell growth and concentration in a dynamic environment of incubator/shaker. In order to reduce power consumption and make a wireless cell culture monitoring system practical, several methods of temperature compensation are used to replace a method of controlling the temperature of sensing module. Furthermore its power consumption can be significantly reduced by using an adaptive and synchronized light pulse detection technique.

Described is a method for the culture of microalgae, comprising: providing a consortium of at least two living species of microalgae; culturing under illumination the consortium in a controllable bioreactor and under non-sterile aqueous culture conditions; and controlling the culture conditions for affecting at least one of the following output: (i) flocculation and/or settling of said consortium of microalgae; and (ii) adhesion of the microalgae to surfaces of the bioreactor; wherein said culture conditions are controlled to promote (i) and/or to minimize (ii), without adversely affecting growth of the consortium of microalgae. It is also possible to control the culture conditions for affecting iii) the protein, carbohydrate, and/or fat content of the said microalgae consortium. A system for carrying out the method is also described.

An inclined reactor of bottom gas-inlet type for aerobic fermentation and a method for aerobic fermentation are provided, a fermenter is provided with a circular inner tank, end covers and a jacket; an airtight fermentation space is formed in the fermenter by the inner tank, an upper end cover and a lower end cover; a feed opening and an exhaust outlet are arranged at an upper part of the fermenter, and a discharge opening is arranged at a lower part of the lower end cover of the fermenter; a length of the fermenter is greater than or equal to a diameter of the fermenter, the fermenter is fixed on a base having a height difference and is hence in an inclined state; an energy-saving stirrer is mounted in the fermenter, and the energy-saving stirrer is formed by connecting several groups of tangential plates or a spiral combination of tangential plates, a radial rod, a stirring rod and a stirring shaft; several groups of air chambers are arranged at an external wall at the bottom of the inner tank of the fermenter, the air chambers are arranged inside the jacket, several aeration nozzles are defined on an inner side of each air chamber, and the aeration nozzles are close to the inner tank.

An information processing apparatus estimates a quality of an antibody produced from cells and a quality of the cells on the basis of a culture state of the cells, searches for the culture state of the cells that improves the estimated quality of the antibody and the estimated quality of the cells, and derives process conditions for cell culture in which a culture state of the cells is the searched culture state.

The invention relates to a method and a system for in-situ monitoring of a biochemical process in a reactor comprising a vessel (5) intended to receive a liquid (7), said system comprising: a measuring device (9) intended to be inserted floating into said vessel 5, said measuring device (9) being instrumented with sensors configured to take measurements relating to the biochemical process at successive instants and to transmit, at said successive instants, observation data representing said measurements; and a control device (11) configured to control the regulation of the biochemical reactor (3) at said successive instants, according to said observation data received from the measuring device (9).

The present invention relates to bioreactor system and method thereof wherein support matrix (2) comprises at last one central shaft and plurality of peripheral shaft being radially surrounds central shaft. Arrays of discs (11) are mounted along the shaft by defining interspatial vicinities between two successive plates. Thus, discs mounted on peripheral shafts are rotated within the interspatial vicinity of discs of central shaft to ensures sufficient mixing and avoid stagnant fluidic zones which is created when discs are mounted closely apart from each other on shafts. Further, plurality of deflector vanes that are axially provided along the length of the central shaft to redirect substantially co-axial direction fluid flow into interior of culture vessel and more specifically towards the central axis. Thus, bioreactor system provides scalable and disposable bioreactor with efficient mixing and homogeneous conditions and thereby supports high density growth and maintenance of cells and other biological material.