An acoustic wave with an acoustic field with a large number of multi-directional gradients can provide an edge effect that be used to form an interface region relative to the acoustic wave. The interface region can block material with certain characteristics related to the nature of the interface region. Other material that is less influenced by the acoustic properties of the interface region can pass through the acoustic wave. This technique permits separation of materials using the edge effect and interface region.

The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof.

Disclosed is a mass-cultivation system for microalgae, including a reactor that contains a cultivation liquid in the interior thereof, wherein the liquid includes functional particles. According to the mass-cultivation system for microalgae according to the present invention, because various functions that are necessary for cultivation of microalgae may be uniformly distributed in a cultivation liquid by allowing functional particles having various functions to flow in the cultivation liquid, a suitable environment may be created based on the cultivation of a large amount of microalgae and the growth of microalgae so that a high efficiency cultivation system may be realized while the problems of mass-cultivation of an existing cultivation system may be solved.

A system for buoyant particle processing includes: a reaction vessel, a stirring mechanism, a set of one or more pumps, and a filter. The system can additionally or alternatively include a set of pathways and/or any other suitable component(s). A method for buoyant particle processing includes: stirring the contents of a reaction vessel; washing a set of buoyant particles; and filtering the contents of the reaction vessel. Additionally or alternatively, the method can include any or all of: preprocessing the set of buoyant particles; adding a set of inputs to the reaction vessel; washing the set of buoyant particles; repeating one or more; and/or any other suitable process(es).

An apparatus and a method for crystallization and supercritical drying of culture solution are provided.

According to the embodiments of the present invention, an apparatus for crystallization and supercritical drying of culture solution to obtain target material by drying a culture solution containing a first solvent and the target material dissolved in the first solvent comprises a high pressure container to accommodate the culture solution, a first supply unit connected to the high pressure container to supply a second solvent to the high pressure container, a second supply unit connected to the high pressure container to supply a third solvent to the high pressure container, a precooler disposed adjacent to the first supply unit to precool the second solvent discharged from the first supply unit, and a preheater disposed adjacent to the high pressure container to preheat the second solvent and the third solvent supplied to the high pressure container.

According to the embodiments of the present invention, a method for crystallization and supercritical drying of culture solution to obtain target material by drying a culture solution containing a first solvent and the target material dissolved in the first solvent comprises crystallizing the target material by replacing the first solvent with a second solvent in the culture solution, and changing a phase of the second solvent to a supercritical phase.

A cell picking device for sucking cells from a liquid sample in a sample container includes a sucking member to which a pipette tip is attachable, a driver that moves the sucking member and performs suction through the sucking member and the pipette tip, a work mode switcher that switches a work mode of the driver between a first mode and a second mode, and a controller that controls the driver.

The present invention provides a medical device and a method for the selective separation of a biological sample of a mammal into a first portion and a second portion. It comprises a first layer comprising a first reservoir for receiving the biological sample and for retaining the first portion of the sample, and a second layer comprising a second reservoir for receiving the second portion of the sample. Between the first layer and the second layer a third layer is provided, wherein the third layer comprises a plurality of channels configured to provide a fluid communication between the first reservoir and the second reservoir. Furthermore, between the first layer and the second layer a fourth layer adjacent to the third layer is provided, wherein the fourth layer comprises and/or is configured as a separation layer. At least the third and fourth layer are configured to selectively separate the biological sample between the first reservoir and the second reservoir into the first portion and the second portion of the sample. According to the invention, the layers are to be understood to be stackable in a substantially vertical plane, forming a three-dimensional layered structure.

A cell suspension treatment apparatus has a circulation circuit and a filling liquid supply source that supplies a filling liquid to the circulation circuit. The circulation circuit includes a hollow fiber membrane filter, a reservoir, a pump that is provided on a downstream side of the reservoir and on an upstream side of the hollow fiber membrane filter, and a valve that is provided on the downstream side of the reservoir and on an upstream side of the pump. The filling liquid supply source is connected to a portion of the circulation circuit between the first valve and the pump. After the concentrated cell suspension is stored in the reservoir, in a state where the valve is closed and the pump is driven, the filling liquid supply source starts supplying the filling liquid to the circulation circuit to push the cell suspension, which remains in a portion of the circulation circuit from the pump to the inlet port of the reservoir, to flow toward the reservoir by the filling liquid.

A cell activation reactor and a cell activation method are provided. The cell activation reactor includes a body, a rotating part, an upper cover, a microporous film, and multiple baffles. The body has an accommodating space, which is suitable for accommodating multiple cells and multiple magnetic beads. The rotating part is disposed in the accommodating space and includes multiple impellers. The microporous film is disposed in the accommodating space and covers multiple holes of the accommodating space. The baffles are disposed in the body. When the rotating part is driven to rotate, the interaction between the baffles and the impellers separates the cells and the magnetic beads.

An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber.