This sample treating device 1000 is provided with: a treating stage 110 for treating a sample by mixing the sample and a plurality of solutions; a first motor 812 for rotating the treating stage 110 around a first rotation shaft 810; a second motor for rotating the treating stage 110 around a second shaft 820; and a control unit for controlling the rotations of the treating stage driven by the first rotary motor 812 and the second motor. The control unit combines the operation of rotating the treating stage 110 around the first rotation shaft 810 and the operation of rotating the treating stage 110 around the second rotation shaft, thereby treating the sample.

A system includes a bioreactor having an inlet and an outlet, a cell-media recirculation loop between the outlet of the bioreactor and the inlet of the bioreactor, and a mature cell separation unit positioned along the cell-media recirculation loop wherein the mature cell separation unit is configured for performing separation of mature cells from immature cells and direction of the immature cells back to the inlet of the bioreactor. The system may further include a storage unit for storing the mature cells. The mature cell separation unit may be further configured to direct the mature cells to a mature cell storage unit.

A microorganism screening system includes a container configured to store a liquid containing microorganism particles and a liquid medium, and a microorganism separation device. The microorganism separation device includes a hydrodynamic separation device and a liquid feeding unit configured to supply the liquid from the container to the hydrodynamic separation device. The hydrodynamic separation device includes a curved flow channel having a rectangular cross-section, and is configured to separate the liquid into a first segment containing relatively large microorganism particles and a second segment containing relatively small microorganism particles through use of a vortex flow generated in the liquid flowing through the curved flow channel. Screening for microorganisms can be performed efficiently.

Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced.

Provided are a method of recovering cells cultured on a substrate, the method including: a step 1 of adding a cell detachment solution containing a metal ion chelating agent to the substrate having the cells adhering thereto to bring the cells into contact with the cell detachment solution; a step 2 of applying ultrasonic vibration to the substrate and the cells to detach the cells from the substrate; and a step 3 of obtaining the cells singulated from the cells detached in the step 2, and a cell recovery apparatus capable of implementing the method of recovering cells.

An exchangeable separation insert, a modular centrifugal separator, and a method are disclosed. The exchangeable separation insert includes a rotor casing rotatable about an axis of rotation and a first stationary portion. The exchangeable separation insert includes a ring member which extends concentrically with the axis. The ring member is axially displaceable between a first position, in which the ring member abuts radially against the rotor casing and abuts radially, against the first stationary portion, and a second position, in which the ring member abuts radially against the rotor casing only, or against the first stationary portion only.

A centrifugal separator for separation of a cell culture mixture includes a stationary frame, a rotatable assembly and a drive unit for rotating the rotatable assembly relative the frame around a vertical axis of rotation. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around an axis of rotation. The rotor casing includes a mechanically hermetically sealed inlet and first and second mechanically hermetically sealed liquid outlets. The second mechanically hermetically sealed outlet is arranged at an axial end of the rotor casing opposite and arranged so that a separated cell phase is discharged at the rotational axis. The rotatable assembly includes an exchangeable separation insert and a rotatable member.

A device for capturing biological particles in suspension in a liquid medium. The device includes a container that is open via a lower opening, and a filter membrane fixed on the container in such a way as to close the lower opening. Inside the container are: a buffer made of a porous foam and having a planar face resting on the filter membrane, an absorbent block resting on the buffer and able to absorb the liquid medium when it is in contact with the liquid medium, and a spring designed to impede the expansion and/or movement of the absorbent block away from the lower opening of the container. Also, methods for capturing biological particles in suspension in a liquid medium using a capture device, and preparation a sample intended for biological analysis. Further an analysis apparatus that has a capture device.

The present invention provides a system and a method for the production of cells and/or cell products. The system comprises at least one cell culture unit comprising at least one bioreactor for culturing cells, at least one technical control unit for controlling a cell growth parameters, said technical control unit is at least fluidly connected to the cell culture unit, and at least one air treatment unit for treating ambient air, said air treatment unit is fluidly connected to the cell culture unit. The system is characterized in that the system is autonomous and the bioreactor total volume is at most 1000L.

Process and apparatus for producing exosomes operating continuously, in which a product containing exosomes is extracted from an incubator (1); said product is subjected to tangential filtering in a concentrator (3); the product is fed in two separate flows (20, 23) to two sides (301, 302) of the concentrator (3) separated by a semi-permeable wall obtaining a concentration of the exosomes in one of the two flows; a flow of product enriched with exosomes (24) is extracted from the concentrator; a diluted product (30) after transit through the concentrator is recirculated to the incubator; thermal conditioning (2), gaseous conditioning (4) and in-line pH control are provided.