Techniques for printing living tissues and organs are provided. An example apparatus includes a printing platform, bioink printing module with at least one nozzle designed for bioink dosing, a gel-forming composition printing module containing a UV-module, and a nozzle for dosing gel-forming composition that starts polymerizing via UV radiation. A module is provided for relatively displacing the nozzles and/or the platform, in which the bioink printing module is separated from the gel-forming-composition printing module to prevent UV radiation from reaching the bioink printing module. The radiation is directed predominantly parallel to the printing platform to prevent UV radiation from reaching the biological tissues and/or organs being printed. A multi-functional device capable of combining various printing modes, providing a method of high-resolution printing of living tissues and organs based on UV-induced hydrogel polymerization, and a method of cell protection from UV radiation during the printing process, can be realized.

The present invention provides a method of treating a disorder using a fibromodulin (FMOD) reprogrammed (FReP) cell. The method comprises administering locally to a human being the FReP cell to a site in need thereof of the human being.

The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.

Provided is a cell culture scaffold material having excellent cell adhesion. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and the peptide portion has a cyclic peptide skeleton.

The invention relates to a method for producing a material for preparing a substrate for cultivating living cells. The invention further relates to a platelet lysate material and its use.The solution of the problem underlying the invention is based on the combination of at least two different treatments with different virus inactivation procedures.Combining two or more procedures for inactivation of virus particles and/or virus components ensures that a wide range of viruses (e.g. enveloped and non-enveloped viruses) are inactivated so as to provide a safe product for clinical and pharmaceutical applications. Moreover, a platelet lysate material comprising blood platelet lysate is provided, wherein the material is a liquid or dry material that is essentially devoid of vims particles and/or virus components.

The present invention relates to a trypsin-free cell stamp system and a use thereof. According to the present invention, an increase in the passage number of stem cells can be prevented compared with conventional methods of isolating cells from a cell culture dish, while providing a support, which is an essential condition of cell growth, by introducing the trypsin-free cell stamp system, and cells can be continuously supplied for a polymer-based fiber support without an additional subculture process since the empty space of a cell culture dish is filled as times passes. In addition, the artificial effects on cells can be minimized since the cells migrate to a polymer-based nano/micro-fiber support without other external stimulation, and thus the potency of stem cells is increased, thereby inducing more effective differentiation, such that the present invention, as a cell therapeutic agent, can be utilized in general fields of regenerative medicine and tissue engineering.

The present disclosure relates generally to an osteo-tissue graft capable of promoting bone tissue growth and regeneration, comprising at least one self-assemble peptide and mesenchymal stem cells (MSCs) in accordance with the present invention and a method of preparing such an osteo-tissue graft. The grafts are suitable for treatment of bone disorder or damages through tissue engineering, cellular replacement therapies as well as other applications.

The present disclosure relates to ultrashort peptides capable of forming a gel, to a gel comprising a peptide in accordance with the present disclosure, and to a method of preparing such gel. Such gel is a hydrogel or an organogel. The peptides are suitable bioinks for a bioprinter to build 3D structures through 3D printing as well as other applications.

This invention relates generally to the discovery of novel mammalian lung spheroids and lung spheroid cells and uses thereof.

Microfluidic devices for modeling three-dimensional tissue structures and methods for making and using the same are described herein.