The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.

An object of the present invention is to provide a simple method of producing ergothioneine. The present invention provides a method of producing ergothioneine comprising a step of culturing a microbe belonging to the genus Moniliella in a medium containing a carbon source to allow the microbe to produce ergothioneine.

An object of the present invention is to provide a simple method of producing ergothioneine. The present invention provides a method of producing ergothioneine comprising a step of culturing a microbe belonging to the genus Moniliella in a medium containing a carbon source to allow the microbe to produce ergothioneine.

The present disclosure relates to a process for manufacturing organic chemicals and/or distillate hydrocarbon fuels from waste textiles comprising cellulosic fibers, wherein the process includes providing waste textiles comprising cellulosic fibers, processing the waste textiles into an aqueous slurry of comminuted waste textiles, saccharification of the comminuted waste textiles into monomer sugars in the presence of a catalyst; and processing the monomer sugars into organic chemicals and/or distillate hydrocarbon fuels.

The present disclosure relates to a process for manufacturing organic chemicals and/or distillate hydrocarbon fuels from waste textiles comprising cellulosic fibers, wherein the process includes providing waste textiles comprising cellulosic fibers, processing the waste textiles into an aqueous slurry of comminuted waste textiles, saccharification of the comminuted waste textiles into monomer sugars in the presence of a catalyst; and processing the monomer sugars into organic chemicals and/or distillate hydrocarbon fuels.

The present invention relates to a method including culturing a C.sub.1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C.sub.1 compound and/or glycerol as a carbon source, to thereby produce EGT.

The present invention relates to a method including culturing a C.sub.1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C.sub.1 compound and/or glycerol as a carbon source, to thereby produce EGT.

The invention provides a composition for use as a medicament, comprising cells of a recombinant microorganism capable of producing increased amounts of one or more of 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT) and tryptamine (TRM) as compared to the non-recombinant microorganism from which it was derived. The composition finds use in preventing and/or treating TRM-; 5-HTP-, or 5-HT-related disorders of the central nerve system (CNS); enteric nervous system (ENS); gastro intestine (GI) and metabolism in a mammal, and may be orally administered to a mammal in need thereof. Additionally, a composition comprising cells of a recombinant microorganism capable of producing melatonin is provided for use as a medicament, such as for treatment of depression, dementia, cancer and sleep disorder.

The invention provides a composition for use as a medicament, comprising cells of a recombinant microorganism capable of producing increased amounts of one or more of 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT) and tryptamine (TRM) as compared to the non-recombinant microorganism from which it was derived. The composition finds use in preventing and/or treating TRM-; 5-HTP-, or 5-HT-related disorders of the central nerve system (CNS); enteric nervous system (ENS); gastro intestine (GI) and metabolism in a mammal, and may be orally administered to a mammal in need thereof. Additionally, a composition comprising cells of a recombinant microorganism capable of producing melatonin is provided for use as a medicament, such as for treatment of depression, dementia, cancer and sleep disorder.