The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

A composition and a method with active agents to inactivate or kill parasites that attack fish and to loosen parasites that are fastened to the fish are described. The composition can be used for the prevention of and treatment of infestations or infections from parasites on fish.

A composition and a method with active agents to inactivate or kill parasites that attack fish and to loosen parasites that are fastened to the fish are described. The composition can be used for the prevention of and treatment of infestations or infections from parasites on fish.

Herbicidal compositions and methods of controlling undesirable vegetation using a combination of (a) a compound of formula (I): ##STR00001##
or an agriculturally acceptable salt or ester thereof and (b) propyzamide provide control of undesirable vegetation, e.g., in winter/spring oilseed rape, winter/spring canola, vegetables, Brassica spp, ornamentals, rice, wheat, triticale, barley, oats, rye, sorghum, corn/maize, sunflower, row crops, pastures, grasslands, rangelands, fallowland, sugarcane, turf, tree and vine orchards, and industrial vegetation management and rights-of-way.

Herbicidal compositions and methods of controlling undesirable vegetation using a combination of (a) a compound of formula (I): ##STR00001##
or an agriculturally acceptable salt or ester thereof and (b) propyzamide provide control of undesirable vegetation, e.g., in winter/spring oilseed rape, winter/spring canola, vegetables, Brassica spp, ornamentals, rice, wheat, triticale, barley, oats, rye, sorghum, corn/maize, sunflower, row crops, pastures, grasslands, rangelands, fallowland, sugarcane, turf, tree and vine orchards, and industrial vegetation management and rights-of-way.

Herbicidal compositions and methods of controlling undesirable vegetation using a combination of (a) a compound of formula (I): ##STR00001##
or an agriculturally acceptable salt or ester thereof and (b) propyzamide provide control of undesirable vegetation, e.g., in winter/spring oilseed rape, winter/spring canola, vegetables, Brassica spp, ornamentals, rice, wheat, triticale, barley, oats, rye, sorghum, corn/maize, sunflower, row crops, pastures, grasslands, rangelands, fallowland, sugarcane, turf, tree and vine orchards, and industrial vegetation management and rights-of-way.

One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising:
H.sub.3C—(CH.sub.2).sub.n—CH.sub.mCH.sub.mR,
where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound.

One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising:
H.sub.3C—(CH.sub.2).sub.n—CH.sub.mCH.sub.mR,
where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound.

The present invention belongs to the technical field of pesticides, and particularly relates to an herbicidal composition comprising R-pyridyloxycarboxylic acid and derivative and an application thereof. The composition comprises an active ingredient A and an active ingredient B in an herbicidally effective amount, wherein, the active ingredient A is one or more compounds selected from an R-pyridyloxycarboxylic acid represented by formula I and salt, ester derivative thereof,

##STR00001## wherein, R.sub.1, R.sub.2 each independently represent halogen, C1-C6 alkyl, halo C1-C6 alkyl or C3-C6 cycloalkyl; R.sub.3 represents hydrogen, halogen, C1-C6 alkyl or halo C1-C6 alkyl; Q represents C1-C6 alkyl, etc.; Y represents amino, etc.; the active ingredient B is selected from the following one or more compounds or acid or salt or ester derivatives thereof, ALS inhibitor, ACCase inhibitor, PSII inhibitor, HPPD inhibitor, PDS inhibitor, DOXP inhibitor, PPO inhibitor, Synthetic hormone, EPSPS inhibitor, GS inhibitor, PSI inhibitor. The composition is capable of effectively controlling various weeds, and has the following advantages: exhibiting a broad spectrum of weed control, being used in a reduced dose, and being capable of bringing about a synergistic effect and removing resistant weeds.

The present invention belongs to the technical field of pesticides, and particularly relates to an herbicidal composition comprising R-pyridyloxycarboxylic acid and derivative and an application thereof. The composition comprises an active ingredient A and an active ingredient B in an herbicidally effective amount, wherein, the active ingredient A is one or more compounds selected from an R-pyridyloxycarboxylic acid represented by formula I and salt, ester derivative thereof,

##STR00001## wherein, R.sub.1, R.sub.2 each independently represent halogen, C1-C6 alkyl, halo C1-C6 alkyl or C3-C6 cycloalkyl; R.sub.3 represents hydrogen, halogen, C1-C6 alkyl or halo C1-C6 alkyl; Q represents C1-C6 alkyl, etc.; Y represents amino, etc.; the active ingredient B is selected from the following one or more compounds or acid or salt or ester derivatives thereof, ALS inhibitor, ACCase inhibitor, PSII inhibitor, HPPD inhibitor, PDS inhibitor, DOXP inhibitor, PPO inhibitor, Synthetic hormone, EPSPS inhibitor, GS inhibitor, PSI inhibitor. The composition is capable of effectively controlling various weeds, and has the following advantages: exhibiting a broad spectrum of weed control, being used in a reduced dose, and being capable of bringing about a synergistic effect and removing resistant weeds.