The disclosed subject matter relates to a system and method for delivery of therapeutic agents across membranes such as to the inner ear. The system includes a plurality of microneedles that can be delivered to the round window membrane by a delivery device, e.g. catheter, and is capable of controlled penetration of the round window membrane to create temporary and self-closing perforations.

The disclosed subject matter relates to a system and method for delivery of therapeutic agents across membranes such as to the inner ear. The system includes a plurality of microneedles that can be delivered to the round window membrane by a delivery device, e.g. catheter, and is capable of controlled penetration of the round window membrane to create temporary and self-closing perforations.

Disclosed are a manufacturing method for a laser chip and a laser chip. The manufacturing method comprises: step S1, forming a first electroplating substrate on an epitaxial layer; step S2, forming an organic pattern layer on the first electroplating substrate, wherein the pattern layer defines a hollowed-out area and a part of the first electroplating substrate is exposed to the pattern layer by means of the hollowed-out area; step S3, forming a first metal coating on the first electroplating substrate, wherein the first metal coating completely covers the pattern layer and the part of the first electroplating substrate not covered by the pattern layer; and step S4, removing the pattern layer to have a hollow channel formed between the first metal coating and the first electroplating substrate, wherein the channel is provided with at least one inlet and at least one outlet running through the first metal coating.

A method for fabricating aircraft engine external target parts including complex geometries utilizes reusable reconfigurable shape memory polymer and conformable woven braided carbon fiber sleeves. The method includes providing a tubular three-dimensional reusable shape memory polymer mandrel assembly designed for a target part, and heating the shape memory polymer mandrel.

A method for fabricating aircraft engine external target parts including complex geometries utilizes reusable reconfigurable shape memory polymer and conformable woven braided carbon fiber sleeves. The method includes providing a tubular three-dimensional reusable shape memory polymer mandrel assembly designed for a target part, and heating the shape memory polymer mandrel.

A method of electroforming a heat exchanger suitable. The method comprising providing a non-sacrificial carrier plate, providing a first sacrificial element and providing a second sacrificial element. The method comprising electroforming a duct over the first sacrificial element and electroforming a rail over the second sacrificial element. The method comprising removing the first sacrificial element and the second sacrificial element.

An apparatus and method for a mandrel used during an electroforming process. The mandrel is formed of a structural wax and includes a metallic layer utilized to formulate a metal component. During the electroforming process, the mandrel is actively cooled utilizing a closed loop. The closed loop includes the mandrel and a heat exchanger through which a coolant flows.

An apparatus and method for a mandrel used during an electroforming process. The mandrel is formed of a structural wax and includes a metallic layer utilized to formulate a metal component. During the electroforming process, the mandrel is actively cooled utilizing a closed loop. The closed loop includes the mandrel and a heat exchanger through which a coolant flows.

A system and method for rotary motion with vacuum sealing is provided. The system includes a vacuum chamber, a component mount disposed in the vacuum chamber, and a base. A bellows is disposed between the base and the component mount, and the bellows provides a seal between the base and the component mount. The bellows, the base, and the component mount define an actuator compartment therebetween. An actuator is disposed in the actuator compartment. The actuator is configured to rotate the component mount relative to the base in order to align a component disposed on the component mount. Rotation of the component mount relative to the base causes torsional elastic deformation of the bellows.

A method of electroforming can be used to prepare a heat exchanger by electroforming the heat exchanger on a mandrel having a smooth and conductive surface. The mandrel is in the shape of at least part of the heat exchanger, and is removed from the electroformed heat exchanger.