The present disclosure relates to crystalline solids comprising a compound of Formula (I), ##STR00001##
wherein R is n-propyl, and methods of making compounds of Formula (I) wherein R is C1-C4 alkyl or C2-C4 alkenyl. The present disclosure also relates to crystalline solids comprising a compound of Formula (II), ##STR00002## The present disclosure further relates to methods of preparing the crystalline solids, and pharmaceutical preparations of the crystalline solids, and use of such pharmaceutical preparations in treatment of diseases and conditions.

Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.

Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.

In one aspect, the invention relates to a compound of the structure:

##STR00001##

or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

In one aspect, the invention relates to a compound of the structure:

##STR00001##

or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

The present technology relates to an ionic plastic crystal comprising at least one delocalized anion paired with at least one an organic guanidine, amidine or phosphazene organic superbase-derived cation for use in electrochemical applications, particularly in electrochemical accumulators such as batteries, electrochromic devices, and supercapacitors. The present technology also relates to an ionic plastic crystal composition, an ionic plastic crystal-based solid electrolyte composition, an ionic plastic crystal-based solid electrolyte, an electrode material comprising the ionic plastic crystal or the ionic plastic crystal composition. Their uses in electrochemical cells and electrochemical accumulators as well as their processes of manufacturing and an NHO-stabilized intermediary ion-neutral complex are also described.

The invention relates to a continuous method for obtaining a crystalline monosaccharide, comprising: continuous crystallization of the monosaccharide in a main crystallizer (10), wherein crystallization by evaporation and/or crystallization by cooling is carried out continuously on a crystal suspension in the main crystallizer in order to allow crystals of the monosaccharide to grow in the crystal suspension; separation of crystals of the monosaccharide out of the crystal suspension to obtain crystalline monosaccharide; continuous formation of a mass of crystallization magma for the main crystallizer (10) in a cascade, wherein the cascade comprises at least one first stage (13) and a final stage (15) connected in series and each stage comprises at least one pre-crystallizer (13A, 15A), wherein, in the at least one pre-crystallizer (13A) of the first stage (13), a solution is seeded with monosaccharide by means of monosaccharide seed crystals in order to obtain a pre-crystallization magma, and a mass of crystallization magma for the downstream stage (14, 15) is formed from the pre-crystallization magma by means of crystallization by cooling and/or crystallization by evaporation, and wherein a solution containing monosaccharide and a mass of crystallization magma from the upstream stage is supplied to the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) to obtain a pre-crystallization magma, and in the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) a mass of crystallization magma for the main crystallizer (10) is formed from the pre-crystallisation magma by means of crystallization by cooling and/or crystallization by evaporation; the continuous supply of a solution containing the monosaccharide and a mass of crystallization magma from the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) of the cascade to the main crystallizer (10) to provide the crystal suspension.

A method includes forming a layer of molecular feedstock over a surface of a substrate, the molecular feedstock including a chiral molecule, forming crystal nuclei from the molecular feedstock within a nucleation region of the layer, and growing the crystal nuclei to form an organic solid crystal (OSC) thin film. A chiral molecule-containing organic solid crystal thin film may have a refractive index and birefringence that can be actively tuned via charge injection. An organic solid crystal (OSC) thin film including a single enantiomer of a chiral organic molecule may be configured to propagate a selected handedness of circularly polarized light.

A method includes forming a layer of molecular feedstock over a surface of a substrate, the molecular feedstock including a chiral molecule, forming crystal nuclei from the molecular feedstock within a nucleation region of the layer, and growing the crystal nuclei to form an organic solid crystal (OSC) thin film. A chiral molecule-containing organic solid crystal thin film may have a refractive index and birefringence that can be actively tuned via charge injection. An organic solid crystal (OSC) thin film including a single enantiomer of a chiral organic molecule may be configured to propagate a selected handedness of circularly polarized light.

An organic solid crystal (OSC) thin film includes an organic crystalline phase, where the organic crystalline phase includes a chiral molecule. A chiral molecule-containing organic solid crystal thin film may have a refractive index and birefringence that can be actively tuned via charge injection. An organic solid crystal thin film including a single enantiomer of a chiral organic molecule may be configured to propagate a selected handedness of circularly polarized light.