Systems and methods for tracking and management of a distributed ledger including information for a batch of radiopharmaceutical material are disclosed. Certain examples provide a computer-implemented method of managing radiopharmaceutical material including tracking, using at least one processor, a status of a batch of radiopharmaceutical material, the status to include a type, a quantity, and a timestamp associated with the batch of radiopharmaceutical material; generating a record in a first copy of a distributed ledger using the type, quantity, and timestamp associated with the batch of radiopharmaceutical material; updating the record based on at least one of usage of the batch of radiopharmaceutical material, resale of at least a portion of the batch of radiopharmaceutical material, and decay of the batch of radiopharmaceutical material; and sharing the record with a second copy of the distributed ledger.

Systems and methods for tracking and management of a distributed ledger including information for a batch of radiopharmaceutical material are disclosed. Certain examples provide a computer-implemented method of managing radiopharmaceutical material including tracking, using at least one processor, a status of a batch of radiopharmaceutical material, the status to include a type, a quantity, and a timestamp associated with the batch of radiopharmaceutical material; generating a record in a first copy of a distributed ledger using the type, quantity, and timestamp associated with the batch of radiopharmaceutical material; updating the record based on at least one of usage of the batch of radiopharmaceutical material, resale of at least a portion of the batch of radiopharmaceutical material, and decay of the batch of radiopharmaceutical material; and sharing the record with a second copy of the distributed ledger.

A chimeric antigen receptor (CAR) cell library is established through the fusion of a cell and a vector assembly. The vector assembly carries three genetic elements corresponding to a plurality of first genetic elements encoding one or more idiotype CARs, a second genetic element carrying one or more genetic circuits, and a third genetic element encoding one or more inducible proteins, respectively. The one or more genetic circuits are pre-programmed and are each a combination of a cis-regulatory factor and a transcription factor; and the one or more inducible proteins include one or two selected from the group consisting of a drug resistance protein and a suicide protein. By designing a CAR library-genetic circuit-inducible protein coupling scheme, the cell library construction and screening for complex and unknown disease target antigens are realized, such as to solve the problems that there are complex, diverse, and variable antigens.

A chimeric antigen receptor (CAR) cell library is established through the fusion of a cell and a vector assembly. The vector assembly carries three genetic elements corresponding to a plurality of first genetic elements encoding one or more idiotype CARs, a second genetic element carrying one or more genetic circuits, and a third genetic element encoding one or more inducible proteins, respectively. The one or more genetic circuits are pre-programmed and are each a combination of a cis-regulatory factor and a transcription factor; and the one or more inducible proteins include one or two selected from the group consisting of a drug resistance protein and a suicide protein. By designing a CAR library-genetic circuit-inducible protein coupling scheme, the cell library construction and screening for complex and unknown disease target antigens are realized, such as to solve the problems that there are complex, diverse, and variable antigens.

Provided are a novel biomarker for a brain tumor and a method for using the same. A method for detecting a brain tumor, the method comprising the step of detecting specific miRNA as biomarker.

Provided is an adhesive tape for collecting skin indigenous microorganisms, the adhesive tape being capable of providing improved collection yields of skin indigenous microorganisms on a skin surface. This adhesive tape is for collecting skin indigenous microorganisms, is used to collect skin indigenous microorganism on a skin surface, and comprises a base material and an adhesive layer provided on at least a portion of a surface of the base material, wherein the adhesive layer contains an adhesive, and the adhesive contains a rubber adhesive. The adhesive tape has an adhesive strength of 10.0 N or more when a 12 mm-wide test piece thereof is pressure-bonded to a Bakelite plate by one reciprocation of a 2 kg roller and then measured for adhesive strength at a pulling speed of 300 mm/min and a pulling angle of 90° according to JIS Z 0237: 2009, and the adhesive tape has a peel strength of 0.25 N or more when a 12 mm-wide test piece thereof is measured using a silicone-treated fine paper sheet as a release sheet and measured for peel strength at a pulling speed of 300 mm/min and a pulling angle of 180° according to JIS Z 0237: 2009.

The present invention relates to a method for producing a panel of cells (i.e. a cell library) expressing various different mutant variants of a protein of interest, wherein only one of said mutant variants is expressed per cell from a single gene copy. The present invention also relates to a method or cell library for identifying a mutant variant of a protein of interest having a different or modified biological activity as compared to the corresponding wild-type protein of interest. According to the present invention the identified mutant variant of a protein of interest may be applied for white biotechnology.

The present invention relates to a method for producing a panel of cells (i.e. a cell library) expressing various different mutant variants of a protein of interest, wherein only one of said mutant variants is expressed per cell from a single gene copy. The present invention also relates to a method or cell library for identifying a mutant variant of a protein of interest having a different or modified biological activity as compared to the corresponding wild-type protein of interest. According to the present invention the identified mutant variant of a protein of interest may be applied for white biotechnology.

According to an embodiment, there are provided a screening culture medium that enables a convenient and quick examination for the presence of Candida auris, and a screening method. According to at least one embodiment, the screening culture medium contains an enzyme substrate, in which the screening culture medium is used for screening Candida auris based on an ability to degrade the enzyme substrate, the enzyme substrate including raffinose and xylose. According to another embodiment, the screening method uses the screening culture medium.

Provided herein are methods to identify TCR-recognizing cancer-specific antigens, and TCR-engineered T cells having antigen-specific cytotoxic activity. Provided herein are engineered T lymphocytes produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the engineered T lymphocytes described herein. Provided herein are antibodies, or fragments thereof, produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the antibodies described herein to a subject. In some embodiments, the therapeutic compositions (e.g., engineered lymphocytes, antibodies, etc.) and methods herein are provided as part of a kit or system.