The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO.sub.2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a break-through of NO.sub.2, and providing an indication of the remaining useful life and/or break-through.

Various systems, devices, NO.sub.2 absorbents, NO.sub.2 scavengers and NO.sub.2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

Various systems, devices, NO.sub.2 absorbents, NO.sub.2 scavengers and NO.sub.2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

A device and method for calibrating a delivery device includes providing a container A containing a nitrite, providing a container B containing an acid, releasing the contents of containers A and B, allowing the nitrite and acid to mix, waiting for a predetermined time, allowing air to combine with the mixture, and using NO and traces of NO.sub.2 to check and calibrate NO and NO.sub.2 sensors.

A device and method for calibrating a delivery device includes providing a container A containing a nitrite, providing a container B containing an acid, releasing the contents of containers A and B, allowing the nitrite and acid to mix, waiting for a predetermined time, allowing air to combine with the mixture, and using NO and traces of NO.sub.2 to check and calibrate NO and NO.sub.2 sensors.

Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

The object of the present invention is to provide a stable isotope enrichment device and a stable isotope enrichment method capable of reducing the discharge amount of toxic or combustible substances or substances causing environmental load in the atmosphere and reducing the amount of raw materials used. The present invention provides a stable isotope enrichment device, including: a distillation column group in which a plurality of distillation columns are connected in a cascade; a raw material supply line (30) that supplies a raw material into a first distillation column (1); a product line (31) that withdraws a product from another distillation column located on the secondary side of the first distillation column (1); an isotope-depleted fluid withdraw line (32) that withdraws an isotope-depleted gas or an isotope-depleted liquid from the first distillation column (1) or another distillation column located on the primary side of the one distillation column (1); an isotope exchange reactor (22) at which the isotope-depleted gas or the isotope-depleted liquid is subjected to an isotope exchange reaction, the isotope-depleted gas or the isotope-depleted liquid is regenerated such that the concentration of molecules containing a target stable isotope in the isotope-depleted gas or the isotope-depleted liquid approaches the natural abundance ratio, and an isotope-regenerated gas or an isotope-regenerated liquid is produced; and an isotope-regenerated fluid return line (33) that re-supplies the isotope-regenerated gas or the isotope-regenerated liquid into the first distillation column (1).

The object of the present invention is to provide a stable isotope enrichment device and a stable isotope enrichment method capable of reducing the discharge amount of toxic or combustible substances or substances causing environmental load in the atmosphere and reducing the amount of raw materials used. The present invention provides a stable isotope enrichment device, including: a distillation column group in which a plurality of distillation columns are connected in a cascade; a raw material supply line (30) that supplies a raw material into a first distillation column (1); a product line (31) that withdraws a product from another distillation column located on the secondary side of the first distillation column (1); an isotope-depleted fluid withdraw line (32) that withdraws an isotope-depleted gas or an isotope-depleted liquid from the first distillation column (1) or another distillation column located on the primary side of the one distillation column (1); an isotope exchange reactor (22) at which the isotope-depleted gas or the isotope-depleted liquid is subjected to an isotope exchange reaction, the isotope-depleted gas or the isotope-depleted liquid is regenerated such that the concentration of molecules containing a target stable isotope in the isotope-depleted gas or the isotope-depleted liquid approaches the natural abundance ratio, and an isotope-regenerated gas or an isotope-regenerated liquid is produced; and an isotope-regenerated fluid return line (33) that re-supplies the isotope-regenerated gas or the isotope-regenerated liquid into the first distillation column (1).

An adhesive bandage that is capable of delivering nitric oxide gas to skin is generally disclosed. The bandage may be used for topical skin therapy of a patient, such as, for example, to promote healing of a wound or condition, or to provide exogenous nitric oxide supplementation.

An adhesive bandage that is capable of delivering nitric oxide gas to skin is generally disclosed. The bandage may be used for topical skin therapy of a patient, such as, for example, to promote healing of a wound or condition, or to provide exogenous nitric oxide supplementation.