Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.

A nitric oxide administration device 14 includes a second flow path 201 including an intake port 201a and an NO supply port 201b, a discharge unit 205 which is arranged in the second flow path 201 and which generates NO from air introduced via the intake port 201a, generated NO being supplied via the NO supply port 201b, an NO.sub.2 adsorption unit 206 which is arranged downstream of the discharge unit 205 and removes NO.sub.2, a bypass flow path 217 for reflux from downstream of the NO.sub.2 adsorption unit 206 to upstream of the NO.sub.2 adsorption unit 206, and a three-way valve 216 for switching the opening and closing of a flow path from downstream of the NO.sub.2 adsorption unit 206 to the NO supply port 201b.

A process and system are disclosed for producing lithium oxide from lithium nitrate. In the process and system, the lithium nitrate is thermally decomposed in a manner such that a fraction of the lithium nitrate forms lithium oxide, and such that a remaining fraction of the lithium nitrate does not decompose to lithium oxide. The thermal decomposition may be terminated after a determined time period to ensure that there is a remaining fraction of lithium nitrate and to thereby produce a lithium oxide in lithium nitrate product. The lithium oxide in lithium nitrate product may have one or more transition-metal oxides, hydroxides, carbonates or nitrates added thereto to form a battery electrode. The lithium oxide in lithium nitrate product may alternatively be subjected to carbothermal reduction to produce lithium metal.

A nitric oxide administration device 1 includes a first flow path 101 including a first intake port 101a and an oxygen supply port 101b, an oxygen generation unit 100 which is arranged in the first flow path 101 and which generates concentrated oxygen from air introduced via the first intake port 101a, the generated concentrated oxygen being supplied via the oxygen supply port 101b, a second flow path 201 which is branched from the first flow path 101 and which includes an NO supply port 201b, and an NO generation unit 200 which is arranged in the second flow path 201 and which generates NO from gas distributed from the first flow path 101, the generated NO being supplied via the NO supply port 201b.

A method of forming a stream having a therapeutic concentration of nitric oxide (NO) is disclosed, along with an apparatus and system suitable to accomplish this method.

A relay administration device 50 for use in connection to a nitric oxide administration device 20 which supplies NO generated from air, includes an NO densitometer 506, a flowmeter 507 or pressure gauge 504, a control unit 600 which calculates a dosage of NO to be administered to a patient based on an NO concentration measured by the NO densitometer 506 and a value of the flowmeter 507 or the pressure gauge 504, and a two-way valve 505 which is configured to increase a flow rate when the calculated dosage is less than a predetermined value and to decrease the flow rate when the calculated dosage is greater than a predetermined value.

An example of a nitric oxide (NO) generating system includes an NO generating formulation, having: a stable NO donor/adduct; a hydrophilic binder; and an additive. The additive is to control a rate of release of NO from the stable NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light. This example NO generating system further includes an inhalation device in operative contact with the NO generating formulation.

An example of a nitric oxide (NO) generating system includes an NO generating formulation, having: a stable NO donor/adduct; a hydrophilic binder; and an additive. The additive is to control a rate of release of NO from the stable NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light. This example NO generating system further includes an inhalation device in operative contact with the NO generating formulation.

Systems and methods for generating nitric oxide are disclosed. A nitic oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.