The present invention relates to a method for producing purified water comprising a step of passing water through an ultrafiltration means and a mixed bed ion exchanger comprising comprising beads having a pore size of 20-100 nm, wherein the ultrafiltration means is located upstream of said mixed bed ion exchanger, as well as to a module comprising an ultrafiltration means and a mixed bed ion exchanger and a water treatment system for producing ultrapure water comprising ultrafiltration means and a mixed bed ion exchanger.

A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.

The ultrapure-water production system includes an auxiliary treatment apparatus and a dead-end filtration apparatus. The auxiliary treatment apparatus treats water such that the number of microparticles present in water treated by the auxiliary treatment apparatus is 800 to 1200 particles/mL. The dead-end filtration apparatus includes a filtration membrane that is a microfiltration membrane having pores formed in the surface of the membrane at an opening ratio of 50% to 90% with a size of 0.05 to 1 m, and having a thickness of 0.1 to 1 mm, or an ultrafiltration membrane having pores formed in the surface of the membrane with a size of 0.005 to 0.05 m, the number of the pores being 1E13 to 1E15 pores/m.sup.2, the ultrafiltration membrane having a thickness of 0.1 to 1 mm and a transmembrane pressure of 0.02 to 0.10 MPa at a permeation flux of 10 m.sup.3/m.sup.2/d.

An ion exchanging unit exchanging ions contained in water includes a container for storing a plurality of ion exchange resins, a water supplying path through which to supply water to the container, a pure water discharging path through which to discharge water which has been ion-exchanged by the ion exchange resins, from the container, and a flow suppressing portion suppressing flow of the ion exchange resins by pressing downward the ion exchange resins stored in the container from above. The flow suppressing portion includes a pressing member placed on an upper surface of the ion exchange resins, the pressing member following the ion exchange resins which shrink more in volume as the ion exchange resins are used longer and then moving downward.

A water purification apparatus includes a bottomed cylindrical container tank, a lid member for fluid-tightly closing an upper opening of the container tank, an upper filter which forms an upper space between the lid member and itself, a lower filter which forms a lower space between a bottom plate of the container tank and itself, a water passage pipe which passes through the upper and lower filters and which establishes a communication between the upper and lower spaces, and an ion-exchange resin loaded in a space defined by the container tank, the upper and lower filters and the water passage pipe. The lid member has a water supply pipe for supplying water to the upper space, and an overflow pipe which connects to the water passage pipe. A water conveyance pipe for discharging the pure water in the container tank to outside is connected to the lower space.

Provided is a method of washing a hollow fiber membrane device which can efficiently remove fine particles while limiting the impact of an ultrapure water production system on the starting time. The method of washing a hollow fiber membrane device includes washing a hollow fiber membrane device with an alkaline aqueous solution before the hollow fiber membrane device is installed in an ultrapure water production system. The hollow fiber membrane device is washed by means of a washing device that is different from the ultrapure water production system.

The level of cleanliness of a hollow fiber membrane device is evaluated before it is installed in an ultrapure water production system. A method of evaluating the level of cleanliness of the hollow fiber membrane device includes capturing fine particles in permeating water by means of a first filter membrane, wherein the permeating water is ultrapure water that permeates through the hollow fiber membrane device before the hollow fiber membrane device is installed in an ultrapure water production system; and analyzing the fine particles that are captured by the filter membrane.

Provided are filtration media and matrixes comprising a pulverized powder of ion exchange resin and a polymeric binder. The resin can be pulverized to an average particle size in the range of 50 to 250 microns and can comprise a cation exchange resin, an anion exchange resin, a chelating resin, a biologically-related ion exchange resin, or combinations thereof. The media can further comprise activated carbon. The binder can be ultra high molecular weight polyethylene. The filtration media can be used to make matrixes and systems. Methods of making and using the same are also provided.

An ion exchanger includes a housing and a cartridge. The housing has an inlet port, through which coolant flows in, and an outlet port, through which the coolant flows out. The cartridge is detachably attached to the housing. The cartridge is filled with ion-exchange resin. The ion exchanger is configured to remove ions from the coolant through ion exchange when the coolant flowing in the housing passes through the ion-exchange resin. The cartridge includes a bypass route that causes some of the coolant that has flowed into the housing to bypass the ion-exchange resin and flow to the outlet port.

The invention provides a water purification and dispensing system, preferably for producing ultrapure water and offering the purified water at one or more dispensing sites in a desired volume. The water purification and dispensing system comprises a (closed) water recirculation loop including a water inlet for introducing water to be purified, pumping means for pumping water through said water recirculation loop in a flow direction, water purification means for purifying water downstream of said water inlet, a dispensing portion of the water recirculation loop including one or more outlet(s) for purified water branched from said water recirculation loop downstream of said water purification means, a first valve arranged between each outlet and said water recirculation loop, for controlled dispensing of the purified water from said recirculation loop through the respective outlet, a second valve arranged in said dispensing portion of the water recirculation loop downstream of said first valve(s) and upstream of said pumping means, a bypass passage branched from said water recirculation loop and bypassing said dispensing portion of the water recirculation loop including said first valve(s) and said second valve, and a third valve for controlling the flow rate through said bypass passage.