The following discloses a novel model for parasitic worm infection, which is useful for screening for and evaluating the efficacy of antiparasitic agents. In particular, the disclosure provides an immunocompromised mouse model that, for the first time, supports advanced development of Dirofilaria immitis (Di) parasites outside of their definitive hosts. As described herein, early-stage larval forms of Di, the causative agent of Canine Heartworm disease, not only persist in this model, but they develop into mature worms.

This disclosure includes the following components, all intended for the purpose of enhancing plant growth and performance: the capabilities of 1-octen-3-ol, which is a metabolite of Trichoderma strains and formulations thereof, a method for formulating this component or other highly effective compounds into stable formulations, and other materials which are expected to be effective with such components and methods. T. afroharzianum (formerly T. harzianum) produces 1-octen-3-ol (mushroom alcohol) and that at very low concentrations in aerial solution enhances plant growth and productivity, a result that could be duplicated by seed treatments at low concentrations.

This disclosure includes the following components, all intended for the purpose of enhancing plant growth and performance: the capabilities of 1-octen-3-ol, which is a metabolite of Trichoderma strains and formulations thereof, a method for formulating this component or other highly effective compounds into stable formulations, and other materials which are expected to be effective with such components and methods. T. afroharzianum (formerly T. harzianum) produces 1-octen-3-ol (mushroom alcohol) and that at very low concentrations in aerial solution enhances plant growth and productivity, a result that could be duplicated by seed treatments at low concentrations.

The present disclosure relates to fungicidal active compounds, more specifically to benzosultams and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.

The present disclosure relates to fungicidal active compounds, more specifically to benzosultams and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.

Synthesis of a compound (2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide and its use as an insecticidal agent.

Synthesis of a compound (2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide and its use as an insecticidal agent.

At least some aspects of this disclosure include one or more auxinic herbicides with relatively low volatility. Some of these compounds may be especially useful when used in the process of growing commercially important plants. Methods for using these actives to control the growth and spread of unwanted plants and/or to hasten the growth of desirable plants are also disclosed herein.

At least some aspects of this disclosure include one or more auxinic herbicides with relatively low volatility. Some of these compounds may be especially useful when used in the process of growing commercially important plants. Methods for using these actives to control the growth and spread of unwanted plants and/or to hasten the growth of desirable plants are also disclosed herein.

The present invention relates to a composition comprising fibrinogen for increasing the sensitivity of microorganisms for an antimicrobial compound. The invention may be used to alleviate the problem of antimicrobial resistance of microbial biofilms or aggregates, for example of microbial biofilms on medical devices, in particular indwelling devices, or in wound beds. The device or wound bed may be (pre-)coated with fibrinogen to increase antimicrobial susceptibility. The antimicrobial may be supplied separately from or together with the fibrinogen.