The present invention relates to a composition comprising fibrinogen for increasing the sensitivity of microorganisms for an antimicrobial compound. The invention may be used to alleviate the problem of antimicrobial resistance of microbial biofilms or aggregates, for example of microbial biofilms on medical devices, in particular indwelling devices, or in wound beds. The device or wound bed may be (pre-)coated with fibrinogen to increase antimicrobial susceptibility. The antimicrobial may be supplied separately from or together with the fibrinogen.

Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.

Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.

The present invention provides a fungicide composition for agricultural and horticultural use, comprising compound A represented by formula (1) (in formula (1), Xs each independently represents a halogeno group or a C1-6 alkyl group; n represents a number of Xs and is an integer of 0 to 5; X represents a halogeno group; R.sup.1, R.sup.2 and R.sup.3 each independently represents a C1-6 alkyl group, a C1-6 alkoxy group or a hydroxyl group; A.sup.1 and A.sup.2 each independently represents a nitrogen atom or a carbon atom), and at least one compound B selected from the group consisting of pydiflumetofen, pyraziflumid, isofetamid, tolprocarb, fluxametamide, broflanilide, tiadinil, fenoxanil and triflumezopyrim. ##STR00001##

The present invention provides a fungicide composition for agricultural and horticultural use, comprising compound A represented by formula (1) (in formula (1), Xs each independently represents a halogeno group or a C1-6 alkyl group; n represents a number of Xs and is an integer of 0 to 5; X represents a halogeno group; R.sup.1, R.sup.2 and R.sup.3 each independently represents a C1-6 alkyl group, a C1-6 alkoxy group or a hydroxyl group; A.sup.1 and A.sup.2 each independently represents a nitrogen atom or a carbon atom), and at least one compound B selected from the group consisting of pydiflumetofen, pyraziflumid, isofetamid, tolprocarb, fluxametamide, broflanilide, tiadinil, fenoxanil and triflumezopyrim. ##STR00001##

The present invention provides a fungicide composition for agricultural and horticultural use, comprising compound A represented by formula (1) (in formula (1), Xs each independently represents a halogeno group or a C1-6 alkyl group; n represents a number of Xs and is an integer of 0 to 5; X represents a halogeno group; R.sup.1, R.sup.2 and R.sup.3 each independently represents a C1-6 alkyl group, a C1-6 alkoxy group or a hydroxyl group; A.sup.1 and A.sup.2 each independently represents a nitrogen atom or a carbon atom), and at least one compound B selected from the group consisting of pydiflumetofen, pyraziflumid, isofetamid, tolprocarb, fluxametamide, broflanilide, tiadinil, fenoxanil and triflumezopyrim. ##STR00001##

Compositions, devices, and methods are disclosed for treating or preventing fungal infection in an animal are provided. The methods involve exposing the animal to one or more volatile organic compounds (VOCs) in a quantity sufficient to inhibit or reduce fungal growth in the animal. Also disclosed is an automated aerosolization unit (AAU) for delivering compositions, such as the disclosed VOCs, to areas, such as habitats, to treat or prevent fungal infections in animals.

Compositions, devices, and methods are disclosed for treating or preventing fungal infection in an animal are provided. The methods involve exposing the animal to one or more volatile organic compounds (VOCs) in a quantity sufficient to inhibit or reduce fungal growth in the animal. Also disclosed is an automated aerosolization unit (AAU) for delivering compositions, such as the disclosed VOCs, to areas, such as habitats, to treat or prevent fungal infections in animals.

The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy.sup.1, Cy.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.a and R.sup.b is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

The present invention relates to pesticidal mixtures comprising tetramic acids as compound I and a compound II selected from the group consisting of mefentrifluconazole, picarbutrazox, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolyl)oxy]phenyl]propan-2-ol, 2-[2-[(7,8-difluoro-2-methyl-3-quinolyl)oxy]-6-fluoro-phenyl]propan-2-ol and 9-fluoro-2,2-dimethyl-5-(3-quinolyl)-3H 1,4-benzoxazepine.