A complex of formula (I) ##STR00001## wherein M is zirconium or hafnium; each X independently is a sigma ligand; L is a divalent bridge selected from —R′.sub.2C—, —R′.sub.2C—CR′.sub.2—, —R′.sub.2Si—, —R′.sub.2Si—SiR′.sub.2—, —R′.sub.2Ge—, wherein each R′ is independently a hydrogen atom or a C.sub.1-C.sub.20-hydrocarbyl .group optionally containing one or more silicon atoms or heteroatoms of Group 14-16 of the periodic table or fluorine atoms, and optionally two R′ groups taken together can form a ring; R.sup.2 and R.sup.2′ are each independently a C.sub.1-C.sub.20 hydrocarbyl group, —OC.sub.1-20 hydrocarbyl group or —SC.sub.1-20 hydrocarbyl group; R.sup.5 is a —OC.sub.1-20 hydrocarbyl group or —SC.sub.1-20 hydrocarbyl group, said R.sup.5 group being optionally substituted by one or more halo groups; R.sup.5′ is hydrogen or a C.sub.1-20 hydrocarbyl group; —OC.sub.1-20 hydrocarbyl group or —SC.sub.1-20 hydrocarbyl group; said C.sub.1-20 hydrocarbyl group being optionally substituted by one or more halo groups; R.sup.6 and R.sup.6′ are each independently a C.sub.1-20 hydrocarbyl group; —OC.sub.1-20 hydrocarbyl group or —SC.sub.1-20 hydrocarbyl group; each R.sup.1 and R.sup.1′ are independently —CH.sub.2R.sup.x wherein R.sup.x are each independently H, or a C.sub.1-20 hydrocarbyl group, optionally containing heteroatoms.

The invention relates to methods for producing botanical extracts comprising cannabinoids and terpenes using cold extraction with highly polyunsaturated lipid solvents. These methods allow for the extraction of cannabinoids and terpenes while leaving behind impurities that are commonly found in organic solvent extraction methods.

The invention relates to methods for producing botanical extracts comprising cannabinoids and terpenes using cold extraction with highly polyunsaturated lipid solvents. These methods allow for the extraction of cannabinoids and terpenes while leaving behind impurities that are commonly found in organic solvent extraction methods.

Compounds of formula (I): ##STR00001##
wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a COOH, a OH or a OPO(OH).sub.2 group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a COOH, OH or OPO(OH).sub.2 group, then R5 represents a hydrogen atom; when R5 represents a OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl and heterocycloalkyl group;
and the preparation and the therapeutic uses of the compounds of formula (I) as inhibitors and degraders of estrogen receptors, useful especially in the treatment of cancer.

This invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. Specifically, the present invention provides a polymer comprising rigorously alternating AB subunits and methods of formation of the AB alternating polymers. In the polymers and process of the invention, the A monomer is derived from a cyclobutene derivative, and the B monomer is derived from a cyclohexene derivative. The polymerization takes place in the presence of an olefin metathesis catalyst.

This invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. Specifically, the present invention provides a polymer comprising rigorously alternating AB subunits and methods of formation of the AB alternating polymers. In the polymers and process of the invention, the A monomer is derived from a cyclobutene derivative, and the B monomer is derived from a cyclohexene derivative. The polymerization takes place in the presence of an olefin metathesis catalyst.

A complex of formula (I) wherein M is zirconium or hafnium; each X independently is a sigma ligand; L is a divalent bridge selected from R.sub.2C, R.sub.2CCR.sub.2, R.sub.2Si, R.sub.2SiSiR.sub.2, R.sub.2Ge, wherein each R is independently a hydrogen atom or a C.sub.1-C.sub.20-hydrocarbyl group optionally containing one or more silicon atoms or heteroatoms of Group 14-16 of the periodic table or fluorine atoms, and optionally two R groups taken together can form a ring; R.sup.2 and R.sup.2 are each independently a C.sub.1-C.sub.20 hydrocarbyl group, OC.sub.1-hydrocarbyl group or SC.sub.1-20 hydrocarbyl group; R.sup.5 is a OC.sub.1-20 hydrocarbyl group or SC.sub.1-20 hydrocarbyl group, said R.sup.5 group being optionally substituted by one or more halo groups; R.sup.5 is hydrogen or a C.sub.1-20 hydrocarbyl group; OC.sub.1-20 hydrocarbyl group or SC.sub.1-20 hydrocarbyl group; said C.sub.1-20 hydrocarbyl group being optionally substituted by one or more halo groups; R.sup.6 and R.sup.6 are each independently a C.sub.1-20 hydrocarbyl group; C.sub.1-20 hydrocarbyl group or SC.sub.1-20 hydrocarbyl group; each R.sup.1 and R.sup.1 are independently CH.sub.2R.sup.x wherein R.sup.x are each independently H, or a C.sub.1-20 hydrocarbyl group, optionally containing heteroatoms.

##STR00001##

A complex of formula (I) wherein M is zirconium or hafnium; each X independently is a sigma ligand; L is a divalent bridge selected from R.sub.2C, R.sub.2CCR.sub.2, R.sub.2Si, R.sub.2SiSiR.sub.2, R.sub.2Ge, wherein each R is independently a hydrogen atom or a C.sub.1-C.sub.20-hydrocarbyl group optionally containing one or more silicon atoms or heteroatoms of Group 14-16 of the periodic table or fluorine atoms, and optionally two R groups taken together can form a ring; R.sup.2 and R.sup.2 are each independently a C.sub.1-C.sub.20 hydrocarbyl group, OC.sub.1-hydrocarbyl group or SC.sub.1-20 hydrocarbyl group; R.sup.5 is a OC.sub.1-20 hydrocarbyl group or SC.sub.1-20 hydrocarbyl group, said R.sup.5 group being optionally substituted by one or more halo groups; R.sup.5 is hydrogen or a C.sub.1-20 hydrocarbyl group; OC.sub.1-20 hydrocarbyl group or SC.sub.1-20 hydrocarbyl group; said C.sub.1-20 hydrocarbyl group being optionally substituted by one or more halo groups; R.sup.6 and R.sup.6 are each independently a C.sub.1-20 hydrocarbyl group; C.sub.1-20 hydrocarbyl group or SC.sub.1-20 hydrocarbyl group; each R.sup.1 and R.sup.1 are independently CH.sub.2R.sup.x wherein R.sup.x are each independently H, or a C.sub.1-20 hydrocarbyl group, optionally containing heteroatoms.

##STR00001##

A method for converting cedarwood oil into high density fuels including, hydrogenating cedarwood oil in the presence of at least one hydrogenation catalyst to generate hydrogenated cedarwood oil, removing the hydrogenation catalyst from the hydrogenated cedarwood oil, purifying the hydrogenated cedarwood oil to produce a first high density fuel, isomerizing the first high density fuel in the presence of at least one acid catalyst to generate a hydrocarbon mixture including adamantanes, and distilling the adamantane mixture to produce a second alkyl-adamantane high density fuel.

A method for converting cedarwood oil into high density fuels including, hydrogenating cedarwood oil in the presence of at least one hydrogenation catalyst to generate hydrogenated cedarwood oil, removing the hydrogenation catalyst from the hydrogenated cedarwood oil, purifying the hydrogenated cedarwood oil to produce a first high density fuel, isomerizing the first high density fuel in the presence of at least one acid catalyst to generate a hydrocarbon mixture including adamantanes, and distilling the adamantane mixture to produce a second alkyl-adamantane high density fuel.