The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).

The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).

Processes and systems for converting a hydrocarbon-containing feed. The feed and heated particles can be contacted within a pyrolysis zone to effect pyrolysis of at least a portion of the feed to produce a pyrolysis zone effluent and a first gaseous stream rich in olefins and a first particle stream rich in the particles can be obtained therefrom. At least a portion of the first particle stream, an oxidant, and steam can be fed into a gasification zone and contacted therein to effect gasification of at least a portion of coke disposed on the surface of the particles to produce a gasification zone effluent. A second gaseous stream rich in a synthesis gas and a second particle stream rich in heated and regenerated particles can be obtained from the gasification zone effluent. At least a portion of the second particle stream can be fed into the pyrolysis zone.

Processes and systems for converting a hydrocarbon-containing feed. The feed and heated particles can be contacted within a pyrolysis zone to effect pyrolysis of at least a portion of the feed to produce a pyrolysis zone effluent and a first gaseous stream rich in olefins and a first particle stream rich in the particles can be obtained therefrom. At least a portion of the first particle stream, an oxidant, and steam can be fed into a gasification zone and contacted therein to effect gasification of at least a portion of coke disposed on the surface of the particles to produce a gasification zone effluent. A second gaseous stream rich in a synthesis gas and a second particle stream rich in heated and regenerated particles can be obtained from the gasification zone effluent. At least a portion of the second particle stream can be fed into the pyrolysis zone.

A power-to-X system for the utilization of off-gases, includes an electrolyzer for generating hydrogen H2 and oxygen O2, a unit, connected to the electrolyzer, for processing the hydrogen H2, for removing any remaining water H2O and oxygen O2 from the generated stream of hydrogen H2, a compressor, connected to the unit for processing the hydrogen H2, for compressing the hydrogen H2, and a chemical reactor, connected to the compressor, for producing a synthesis gas consisting of hydrogen H2 and carbon dioxide CO2 that can be added. An oxy-fuel combustion system to which non-condensable off-gases from the chemical reactor and oxygen O2 from the electrolyzer can be supplied, and carbon dioxide CO2 generated during the combustion of the off-gases in the oxy-fuel combustion system can be returned to the stream of hydrogen H2 downstream of the electrolyzer via a return line.

A power-to-X system for the utilization of off-gases, includes an electrolyzer for generating hydrogen H2 and oxygen O2, a unit, connected to the electrolyzer, for processing the hydrogen H2, for removing any remaining water H2O and oxygen O2 from the generated stream of hydrogen H2, a compressor, connected to the unit for processing the hydrogen H2, for compressing the hydrogen H2, and a chemical reactor, connected to the compressor, for producing a synthesis gas consisting of hydrogen H2 and carbon dioxide CO2 that can be added. An oxy-fuel combustion system to which non-condensable off-gases from the chemical reactor and oxygen O2 from the electrolyzer can be supplied, and carbon dioxide CO2 generated during the combustion of the off-gases in the oxy-fuel combustion system can be returned to the stream of hydrogen H2 downstream of the electrolyzer via a return line.

A plant complex may include a unit that produces CO.sub.2-containing gases, a gas conducting system for CO.sub.2-containing gases, a gas/liquid separation system, a reformer that is connected to the gas conducting system and where the CO.sub.2-containing gas reacts with H.sub.2 and/or hydrocarbons to give a CO— and H.sub.2-containing synthesis gas mixture. The reformer is connected to a reactor for producing higher alcohols in which the synthesis gas mixture reacts with H.sub.2 to give a gas/liquid mixture containing higher alcohols. For separating off the alcohols of the gas/liquid mixture, the gas/liquid separation system is connected to the reactor for producing higher alcohols.

A plant complex may include a unit that produces CO.sub.2-containing gases, a gas conducting system for CO.sub.2-containing gases, a gas/liquid separation system, a reformer that is connected to the gas conducting system and where the CO.sub.2-containing gas reacts with H.sub.2 and/or hydrocarbons to give a CO— and H.sub.2-containing synthesis gas mixture. The reformer is connected to a reactor for producing higher alcohols in which the synthesis gas mixture reacts with H.sub.2 to give a gas/liquid mixture containing higher alcohols. For separating off the alcohols of the gas/liquid mixture, the gas/liquid separation system is connected to the reactor for producing higher alcohols.

A membrane reactor includes a catalyst layer, a separation membrane, and a buffer layer. The catalyst layer contains a catalyst for promoting a conversion reaction from a feed gas containing hydrogen and carbon oxide to a liquid fuel. The separation membrane is permeable to water vapor which is a byproduct of the conversion reaction. The buffer layer is disposed between the separation membrane and the catalyst layer, and permeable to the water vapor toward the separation membrane.

A membrane reactor includes a catalyst layer, a separation membrane, and a buffer layer. The catalyst layer contains a catalyst for promoting a conversion reaction from a feed gas containing hydrogen and carbon oxide to a liquid fuel. The separation membrane is permeable to water vapor which is a byproduct of the conversion reaction. The buffer layer is disposed between the separation membrane and the catalyst layer, and permeable to the water vapor toward the separation membrane.