The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.

The present invention relates to processes for the reduction by hydrogenation, using molecular H.sub.2, of a C.sub.5-C.sub.20 substrate containing one or two aldehydes functional groups into the corresponding alcohols or diol, characterized in that said process is carried out in the presence of at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the N.sub.1P.sub.3O.sub.2, wherein the coordinating atom N and one coordinating atom P are provided by a first bidentate ligand, and the two other coordinating atoms P.sub.2 are provided by a second bidentate ligand and the coordinating atoms O.sub.2 are provided by two non-linear carboxylate ligands; and optionally of an acidic additive.

The present invention relates to processes for the reduction by hydrogenation, using molecular H.sub.2, of a C.sub.5-C.sub.20 substrate containing one or two aldehydes functional groups into the corresponding alcohols or diol, characterized in that said process is carried out in the presence of at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the N.sub.1P.sub.3O.sub.2, wherein the coordinating atom N and one coordinating atom P are provided by a first bidentate ligand, and the two other coordinating atoms P.sub.2 are provided by a second bidentate ligand and the coordinating atoms O.sub.2 are provided by two non-linear carboxylate ligands; and optionally of an acidic additive.

The present invention relates to an optically active axially chiral -allenic alcohol, a synthesis method and use thereof. The invention relates to a method of preparing a highly optically active chiral -allenic alcohol by using propargyl alcohol, aldehyde and chiral ,-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral -allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The highly optically active axially chiral -allenic alcohol synthesized by the method of the present invention can conveniently synthesize 2,5-dihydrofuran compounds having central chirality and complete chirality, and at the same time can further synthesize axially chiral allenic amine and allenic malonic ester compounds having complete chirality. ##STR00001##

The present invention relates to an optically active axially chiral -allenic alcohol, a synthesis method and use thereof. The invention relates to a method of preparing a highly optically active chiral -allenic alcohol by using propargyl alcohol, aldehyde and chiral ,-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral -allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The highly optically active axially chiral -allenic alcohol synthesized by the method of the present invention can conveniently synthesize 2,5-dihydrofuran compounds having central chirality and complete chirality, and at the same time can further synthesize axially chiral allenic amine and allenic malonic ester compounds having complete chirality. ##STR00001##

The present invention relates to an optically active axially chiral -allenic alcohol, a synthesis method and use thereof. The invention relates to a method of preparing a highly optically active chiral -allenic alcohol by using propargyl alcohol, aldehyde and chiral ,-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral -allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The highly optically active axially chiral -allenic alcohol synthesized by the method of the present invention can conveniently synthesize 2,5-dihydrofuran compounds having central chirality and complete chirality, and at the same time can further synthesize axially chiral allenic amine and allenic malonic ester compounds having complete chirality. ##STR00001##

The present invention concerns 2-methyl-5-[2-methyl-3-methylene-bicyclo[2.2.1]hept-5-en-2-yl)]-2-penten-1-ol in any of its stereometric forms or a lower ester thereof and their use as perfuming ingredient, in particular to impart sandalwood and cedar wood notes.

The present invention concerns 2-methyl-5-[2-methyl-3-methylene-bicyclo[2.2.1]hept-5-en-2-yl)]-2-penten-1-ol in any of its stereometric forms or a lower ester thereof and their use as perfuming ingredient, in particular to impart sandalwood and cedar wood notes.

The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.