The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

##STR00001##

The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

##STR00001##

The polymerization stability and the chemical stability and the water resistance of resin films are improved. A surfactant composition according to an embodiment contains a surfactant (A) represented by general formula (1) and an anionic surfactant (B) having a hydrophobic group different from that of the surfactant (A). In the formula, R.sup.1 represents one or two groups selected from groups below, D.sup.1 represents a polymerizable unsaturated group represented by chemical formula D.sup.1-1 or D.sup.1-2 below, R.sup.2 represents a hydrogen atom or a methyl group, m1 and m2 represent 1 to 2, A.sup.1 represents an alkylene group with 2 to 4 carbon atoms, and m3 represents 1 to 100.

##STR00001##

A compound of general formula (I-1): ##STR00001## wherein the symbols are defined in the specification, has a selective S1P.sub.5 receptor binding activity and modulates the function of an S1P.sub.5 receptor, and can therefore be a therapeutic agent for a S1P.sub.5-mediated disease, for example, neurodegenerative diseases such as schizophrenia, Binswanger's disease and the like.

A compound of general formula (I-1): ##STR00001## wherein the symbols are defined in the specification, has a selective S1P.sub.5 receptor binding activity and modulates the function of an S1P.sub.5 receptor, and can therefore be a therapeutic agent for a S1P.sub.5-mediated disease, for example, neurodegenerative diseases such as schizophrenia, Binswanger's disease and the like.

A composition of matter comprising a) at least one compound of formula ##STR00001## in the form of any one of its isomers or a mixture thereof; wherein R.sup.1 represents a hydrogen atom or a C.sub.1-2 alkyl group; and R represents a group of formula CH.sub.2C(Me).sub.2OH; with R being, relative to position 1, a meta, a para substituent of the aromatic ring or a mixture thereof; and b) at least one compound of formula ##STR00002## in the form of any one of its isomers or a mixture thereof; wherein R.sup.1 and R have the same meaning as defined in formula (I);
their uses as perfuming ingredients as well as perfuming composition and consumer products including such a composition of matter and a process to prepare the composition.

A composition of matter comprising a) at least one compound of formula ##STR00001## in the form of any one of its isomers or a mixture thereof; wherein R.sup.1 represents a hydrogen atom or a C.sub.1-2 alkyl group; and R represents a group of formula CH.sub.2C(Me).sub.2OH; with R being, relative to position 1, a meta, a para substituent of the aromatic ring or a mixture thereof; and b) at least one compound of formula ##STR00002## in the form of any one of its isomers or a mixture thereof; wherein R.sup.1 and R have the same meaning as defined in formula (I);
their uses as perfuming ingredients as well as perfuming composition and consumer products including such a composition of matter and a process to prepare the composition.

The present disclosure relates to new transition metal isonitrile compounds, processes for the production of the compounds and the use of the compounds as catalysts. The disclosure also relates to the use of the metal isonitrile compounds as catalysts for hydrogenation and transfer hydrogenation of compounds containing one or more carbon-oxygen, and/or carbon-nitrogen and/or carbon-carbon double bonds.

The present disclosure relates to new transition metal isonitrile compounds, processes for the production of the compounds and the use of the compounds as catalysts. The disclosure also relates to the use of the metal isonitrile compounds as catalysts for hydrogenation and transfer hydrogenation of compounds containing one or more carbon-oxygen, and/or carbon-nitrogen and/or carbon-carbon double bonds.