Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein R.sup.1 and R.sup.3 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R.sup.2 represents an alkyl group having 1 to 6 carbon atoms, R.sup.4 represents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond. ##STR00001##

A polymer compound comprising a constitutional unit having a group represented by the formula (1): ##STR00001##
wherein Ring A.sup.1A and Ring R.sup.2A represent an aromatic hydrocarbon ring or a heterocyclic ring and these rings each optionally have a substituent, nA represents an integer of 0 to 5, nB represents an integer of 1 to 5, L.sup.A and L.sup.B represent an alkylene group, a cycloalkylene group, an arylene group, a divalent heterocyclic ring group, a group represented by NR, an oxygen atom or a sulfur atom, and R represents a hydrogen atom, an alkyl group or the like, and Q.sup.1 represents a crosslinkable group.

A polymer compound comprising a constitutional unit having a group represented by the formula (1): ##STR00001##
wherein Ring A.sup.1A and Ring R.sup.2A represent an aromatic hydrocarbon ring or a heterocyclic ring and these rings each optionally have a substituent, nA represents an integer of 0 to 5, nB represents an integer of 1 to 5, L.sup.A and L.sup.B represent an alkylene group, a cycloalkylene group, an arylene group, a divalent heterocyclic ring group, a group represented by NR, an oxygen atom or a sulfur atom, and R represents a hydrogen atom, an alkyl group or the like, and Q.sup.1 represents a crosslinkable group.

A process for the stereoselective preparation of a chiral alcohol or a chiral amine, the process comprising reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant comprising a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein:

##STR00001##

Also provided is the use of the chiral trans-diamine of formula (1) in a Grignard reaction and the chiral trans-diamines per se.

A process for the stereoselective preparation of a chiral alcohol or a chiral amine, the process comprising reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant comprising a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein:

##STR00001##

Also provided is the use of the chiral trans-diamine of formula (1) in a Grignard reaction and the chiral trans-diamines per se.

The present invention relates to an optically active axially chiral -allenic alcohol, a synthesis method and use thereof. The invention relates to a method of preparing a highly optically active chiral -allenic alcohol by using propargyl alcohol, aldehyde and chiral ,-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral -allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The highly optically active axially chiral -allenic alcohol synthesized by the method of the present invention can conveniently synthesize 2,5-dihydrofuran compounds having central chirality and complete chirality, and at the same time can further synthesize axially chiral allenic amine and allenic malonic ester compounds having complete chirality. ##STR00001##

The present invention relates to an optically active axially chiral -allenic alcohol, a synthesis method and use thereof. The invention relates to a method of preparing a highly optically active chiral -allenic alcohol by using propargyl alcohol, aldehyde and chiral ,-diphenyl-L-prolinol under the protection of tert-butyldimethylsilyl with an accelerant zinc bromide. The axially chiral -allenic alcohol has the structural formula (I). The method of the present invention has the following advantages: the synthesis route is short, operations are simple, raw materials are readily available, separation and purification are convenient, the substrate has high universality, the total yield is high, and enantioselectivity and diastereoselectivity are high. The highly optically active axially chiral -allenic alcohol synthesized by the method of the present invention can conveniently synthesize 2,5-dihydrofuran compounds having central chirality and complete chirality, and at the same time can further synthesize axially chiral allenic amine and allenic malonic ester compounds having complete chirality. ##STR00001##

A polymer compound comprising a constitutional unit having a group represented by the formula (1):

##STR00001##

wherein Ring A.sup.1A and Ring R.sup.2A represent an aromatic hydrocarbon ring or a heterocyclic ring and these rings each optionally have a substituent, nA represents an integer of 0 to 5, nB represents an integer of 1 to 5, L.sup.A and L.sup.B represent an alkylene group, a cycloalkylene group, an arylene group, a divalent heterocyclic ring group, a group represented by NR, an oxygen atom or a sulfur atom, and R represents a hydrogen atom, an alkyl group or the like, and Q.sup.1 represents a crosslinkable group.

A polymer compound comprising a constitutional unit having a group represented by the formula (1):

##STR00001##

wherein Ring A.sup.1A and Ring R.sup.2A represent an aromatic hydrocarbon ring or a heterocyclic ring and these rings each optionally have a substituent, nA represents an integer of 0 to 5, nB represents an integer of 1 to 5, L.sup.A and L.sup.B represent an alkylene group, a cycloalkylene group, an arylene group, a divalent heterocyclic ring group, a group represented by NR, an oxygen atom or a sulfur atom, and R represents a hydrogen atom, an alkyl group or the like, and Q.sup.1 represents a crosslinkable group.

The present invention relates to catalytic materials for hydrogenation or asymmetric hydrogenation. In particular, the invention relates to iron (II) complexes containing unsymmetrical tetradentate diphosphine (PNNP) ligands with two different nitrogen donor groups useful for catalytic transfer hydrogenation or asymmetric transfer hydrogenation of ketones, aldehydes and imines.