The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.

The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.

The present invention relates to a process for the manufacture of hydroxy-substituted aromatic styryl or stilbene compounds.

The present invention relates to a process for the manufacture of hydroxy-substituted aromatic styryl or stilbene compounds.

The present invention provides, inter alia, a process for producing a compound of formula (I) wherein the substituents are as defined in claim 1. The present invention further provides intermediate compounds utilised in said process, and methods for producing said intermediate compounds.

##STR00001##

The present invention provides, inter alia, a process for producing a compound of formula (I) wherein the substituents are as defined in claim 1. The present invention further provides intermediate compounds utilised in said process, and methods for producing said intermediate compounds.

##STR00001##

A vinylbenzylated phenol compound represented by General Formula (1) below is provided. ##STR00001##
(In General Formula (1), Ar.sup.0 is a bifunctional phenol compound residue having one or more monocyclic or polycyclic aromatic nuclei, R.sup.1 to R.sup.5 may be the same or different and are each hydrogen or a methyl group, and p is an integer of 1 to 4.)

A vinylbenzylated phenol compound represented by General Formula (1) below is provided. ##STR00001##
(In General Formula (1), Ar.sup.0 is a bifunctional phenol compound residue having one or more monocyclic or polycyclic aromatic nuclei, R.sup.1 to R.sup.5 may be the same or different and are each hydrogen or a methyl group, and p is an integer of 1 to 4.)

A vinylbenzylated phenol compound represented by General Formula (1) below is provided. ##STR00001##
(In General Formula (1), Ar.sup.0 is a bifunctional phenol compound residue having one or more monocyclic or polycyclic aromatic nuclei, R.sup.1 to R.sup.5 may be the same or different and are each hydrogen or a methyl group, and p is an integer of 1 to 4.)

The main object of the present invention is to provide a producing method for a 4-isopropyl-3-methylphenol which may be selectively produced, easily refined, and with less odor and coloration. The present invention achieves the object by providing a producing method for a 4-isopropyl-3-methylphenol characterized in that a 4-halogenated-3-methylphenol or a phenol derivative thereof is reacted with an isopropyl metal compound under presence of a catalyst and a solvent.