A terminally-functionalized derivative of a cashew nut shell liquid (CNSL) compound, a method to form a polymer, and an article of manufacture comprising a polymer derived from the terminally-functionalized CNSL derivative. The terminally-functionalized CNSL derivative has two, three, four, or five reactive functional groups. The polymer is prepared by obtaining CNSL compounds, reacting the CNSL compounds to form the terminally-functionalized CNSL derivative, and polymerizing the terminally-functionalized CNSL derivative.

A terminally-functionalized derivative of a cashew nut shell liquid (CNSL) compound, a method to form a polymer, and an article of manufacture comprising a polymer derived from the terminally-functionalized CNSL derivative. The terminally-functionalized CNSL derivative has two, three, four, or five reactive functional groups. The polymer is prepared by obtaining CNSL compounds, reacting the CNSL compounds to form the terminally-functionalized CNSL derivative, and polymerizing the terminally-functionalized CNSL derivative.

A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.

A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.

The present invention provides for a method to produce a deep eutectic solvent (DES) comprising: (a) providing one or more lignin derived monomeric phenol, or a mixture thereof, in a solution, (b) introducing one or more hydrogen acceptors, or a mixture thereof, to the solution, and (c) heating the solution, such that steps (b) and (c) together result in the synthesis of a DES.

The present invention provides for a method to produce a deep eutectic solvent (DES) comprising: (a) providing one or more lignin derived monomeric phenol, or a mixture thereof, in a solution, (b) introducing one or more hydrogen acceptors, or a mixture thereof, to the solution, and (c) heating the solution, such that steps (b) and (c) together result in the synthesis of a DES.

Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G.sub.1 is (CH.sub.2).sub.nC(R.sub.1)(R.sub.2)OH, (CH.sub.2).sub.n; CHO, (CH.sub.2).sub.nC(O)NR.sub.1R.sub.2, (CH.sub.2).sub.nCH (R.sub.1)NR.sub.1R.sub.2, (CH.sub.2).sub.nC(O)OR.sub.3, (CH.sub.2).sub.nCH(R.sub.1)OR.sub.3, or (CH.sub.2).sub.nC(O)R.sub.3; G.sub.2 and G.sub.4 are independently H, OH, F, or Cl, where G.sub.2 can also be NH.sub.2; G.sub.3 and G.sub.5 are independently (H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, (CH.sub.2).sub.nC.sub.3H.sub.5, optionally substituted C.sub.1-C.sub.6 alkyl, optionally substituted C.sub.2-C.sub.6 alkenyl, C(O)R.sub.3, or CH(OH)R.sub.3; and G.sub.6 is H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, or (CH.sub.2).sub.nCOOH, wherein ?n is an integer selected from 0 to 5, ?R.sub.1 and R.sub.2 are independently selected from H and optionally substituted C.sub.1-C.sub.6 alkyl group, and ?R.sub.3 is an optionally substituted C.sub.1-C.sub.6 alkyl group or when present on G.sub.1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.

##STR00001##

Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G.sub.1 is (CH.sub.2).sub.nC(R.sub.1)(R.sub.2)OH, (CH.sub.2).sub.n; CHO, (CH.sub.2).sub.nC(O)NR.sub.1R.sub.2, (CH.sub.2).sub.nCH (R.sub.1)NR.sub.1R.sub.2, (CH.sub.2).sub.nC(O)OR.sub.3, (CH.sub.2).sub.nCH(R.sub.1)OR.sub.3, or (CH.sub.2).sub.nC(O)R.sub.3; G.sub.2 and G.sub.4 are independently H, OH, F, or Cl, where G.sub.2 can also be NH.sub.2; G.sub.3 and G.sub.5 are independently (H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, (CH.sub.2).sub.nC.sub.3H.sub.5, optionally substituted C.sub.1-C.sub.6 alkyl, optionally substituted C.sub.2-C.sub.6 alkenyl, C(O)R.sub.3, or CH(OH)R.sub.3; and G.sub.6 is H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, or (CH.sub.2).sub.nCOOH, wherein ?n is an integer selected from 0 to 5, ?R.sub.1 and R.sub.2 are independently selected from H and optionally substituted C.sub.1-C.sub.6 alkyl group, and ?R.sub.3 is an optionally substituted C.sub.1-C.sub.6 alkyl group or when present on G.sub.1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.

##STR00001##

The present invention relates to a compound of formula (I), in particular for the use thereof for depigmenting, lightering and/or bleaching the skin. (I) In which R.sub.1 and R.sub.2, which may be identical or different, denote hydrogen, or a COR5 radical in which R5 denotes a linear C.sub.1-C.sub.10 or branched C.sub.3-C.sub.10 alkyl radical, preferably a linear C.sub.1-C.sub.6 or branched C.sub.3-C.sub.6 alkyl radical, more preferentially a linear C.sub.1-C.sub.4 alkyl radical, R.sub.3 denotes a linear C.sub.1-C.sub.6 or branched C.sub.3-C.sub.6 alkyl radical, preferably a linear C.sub.1-C.sub.4 or branched C.sub.3-C.sub.4 alkyl radical, and R.sub.4 denotes H, a linear C.sub.1-C.sub.6 or branched C.sub.3-C.sub.6 alkyl radical, or a COR5 radical, and also the salts thereof, the solvates thereof and the optical isomers thereof, and the racemic mixtures thereof, alone or as a mixture. The present invention also relates to the novel compounds (I) and also to the process for preparing same and to a cosmetic process for depigmenting the skin using such compounds (I). ##STR00001##

The present invention relates to a compound of formula (I), in particular for the use thereof for depigmenting, lightering and/or bleaching the skin. (I) In which R.sub.1 and R.sub.2, which may be identical or different, denote hydrogen, or a COR5 radical in which R5 denotes a linear C.sub.1-C.sub.10 or branched C.sub.3-C.sub.10 alkyl radical, preferably a linear C.sub.1-C.sub.6 or branched C.sub.3-C.sub.6 alkyl radical, more preferentially a linear C.sub.1-C.sub.4 alkyl radical, R.sub.3 denotes a linear C.sub.1-C.sub.6 or branched C.sub.3-C.sub.6 alkyl radical, preferably a linear C.sub.1-C.sub.4 or branched C.sub.3-C.sub.4 alkyl radical, and R.sub.4 denotes H, a linear C.sub.1-C.sub.6 or branched C.sub.3-C.sub.6 alkyl radical, or a COR5 radical, and also the salts thereof, the solvates thereof and the optical isomers thereof, and the racemic mixtures thereof, alone or as a mixture. The present invention also relates to the novel compounds (I) and also to the process for preparing same and to a cosmetic process for depigmenting the skin using such compounds (I). ##STR00001##