A method for improving preservation stability of 2,2-difluoroacetaldehyde according to the present invention include at least: a first step of forming a 2,2-difluoroacetaldehyde-alcohol composite system in which a 2,2-difluoroacetaldehyde hemiacetal coexists with an excess alcohol, wherein the total molar amount of the alcohol is 1.15 to 4.00 times the total molar amount of 2,2-difluoroacetaldehyde; and a second step of storing, in a storage container, the 2,2-difluoroacetaldehyde-alcohol composite system formed in the first step. It is possible by this method to suppress the conversion of the 2,2-difluoroacetaldehyde hemiacetal to a dimer and maintain the original aldehyde activity of the target compound with less composition change over a long term.

The present invention provides a preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route of the present invention has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.

The present invention provides a preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route of the present invention has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.

A process of generating a glycerol ether is provided. The process includes reacting isobutylene with an alcohol to obtain a tertiary alkyl ether through an etherification reaction and generating a glycerol ether from the tertiary alkyl ether and glycerol through a transetherification reaction, A system for generating a glycerol ether is also provided.

A process of generating a glycerol ether is provided. The process includes reacting isobutylene with an alcohol to obtain a tertiary alkyl ether through an etherification reaction and generating a glycerol ether from the tertiary alkyl ether and glycerol through a transetherification reaction, A system for generating a glycerol ether is also provided.

A method includes a step of reacting a hydrocarbon-containing gas with an oxygen-containing gas to form a first product blend in a reactor. The first product blend includes a blend of partially oxygenated compounds. The blend of partially oxygenated compounds is provided to one or more reactive distillation stations; and The blend of partially oxygenated compounds is converted to a second product blend at one or more reactive distillation stations. Characteristically, the second product blend includes a mixture comprising a at least two of components selected from acetals, ethers, alcohols, esters, and alkenes.

A method includes a step of reacting a hydrocarbon-containing gas with an oxygen-containing gas to form a first product blend in a reactor. The first product blend includes a blend of partially oxygenated compounds. The blend of partially oxygenated compounds is provided to one or more reactive distillation stations; and The blend of partially oxygenated compounds is converted to a second product blend at one or more reactive distillation stations. Characteristically, the second product blend includes a mixture comprising a at least two of components selected from acetals, ethers, alcohols, esters, and alkenes.

To provide a novel method for producing a halogenated acrylic acid derivative.

A compound represented by the formula (1):

##STR00001##

(wherein each of R.sup.1 and R.sup.2 which are independent of each other, is a hydrogen atom or a monovalent group essentially containing a carbon atom, or R.sup.1 and R.sup.2 together form a ring, R.sup.3 is a monovalent group capable of being desorbed by R.sup.3OH removal reaction, and each of R.sup.4 and R.sup.5 which are independent of each other, is a hydrogen atom or a monovalent group essentially containing a carbon atom) and having a boiling point of at most 500 C., is subjected to R.sup.3OH removal reaction in a vapor phase in the presence of a solid catalyst to obtain an ethene derivative represented by the formula (2):

##STR00002##

the ethene derivative represented by the formula (2) and a halogenated methane represented by the formula (3):

CHXYZ(3)

(wherein each of X, Y and Z which are independent of one another, is a halogen atom) are reacted in the presence of a basic compound and a phase transfer catalyst, to obtain a cyclopropane derivative represented by the formula (4):

##STR00003##

and the cyclopropane derivative represented by the formula (4) is reacted by heating in a liquid phase or in a vapor phase to obtain a halogenated acrylic acid ester derivative represented by the formula (5):

##STR00004##

To provide a novel method for producing a halogenated acrylic acid derivative.

A compound represented by the formula (1):

##STR00001##

(wherein each of R.sup.1 and R.sup.2 which are independent of each other, is a hydrogen atom or a monovalent group essentially containing a carbon atom, or R.sup.1 and R.sup.2 together form a ring, R.sup.3 is a monovalent group capable of being desorbed by R.sup.3OH removal reaction, and each of R.sup.4 and R.sup.5 which are independent of each other, is a hydrogen atom or a monovalent group essentially containing a carbon atom) and having a boiling point of at most 500 C., is subjected to R.sup.3OH removal reaction in a vapor phase in the presence of a solid catalyst to obtain an ethene derivative represented by the formula (2):

##STR00002##

the ethene derivative represented by the formula (2) and a halogenated methane represented by the formula (3):

CHXYZ(3)

(wherein each of X, Y and Z which are independent of one another, is a halogen atom) are reacted in the presence of a basic compound and a phase transfer catalyst, to obtain a cyclopropane derivative represented by the formula (4):

##STR00003##

and the cyclopropane derivative represented by the formula (4) is reacted by heating in a liquid phase or in a vapor phase to obtain a halogenated acrylic acid ester derivative represented by the formula (5):

##STR00004##

To provide a novel method for producing a halogenated acrylic acid derivative.

A compound represented by the formula (1):

##STR00001##

(wherein each of R.sup.1 and R.sup.2 which are independent of each other, is a hydrogen atom or a monovalent group essentially containing a carbon atom, or R.sup.1 and R.sup.2 together form a ring, R.sup.3 is a monovalent group capable of being desorbed by R.sup.3OH removal reaction, and each of R.sup.4 and R.sup.5 which are independent of each other, is a hydrogen atom or a monovalent group essentially containing a carbon atom) and having a boiling point of at most 500 C., is subjected to R.sup.3OH removal reaction in a vapor phase in the presence of a solid catalyst to obtain an ethene derivative represented by the formula (2):

##STR00002##

the ethene derivative represented by the formula (2) and a halogenated methane represented by the formula (3):

CHXYZ(3)

(wherein each of X, Y and Z which are independent of one another, is a halogen atom) are reacted in the presence of a basic compound and a phase transfer catalyst, to obtain a cyclopropane derivative represented by the formula (4):

##STR00003##

and the cyclopropane derivative represented by the formula (4) is reacted by heating in a liquid phase or in a vapor phase to obtain a halogenated acrylic acid ester derivative represented by the formula (5):

##STR00004##