The disclosure relates to a process for continuously producing polyoxymethylene dimethyl ethers at low temperature, pertains to the technical field of polyoxymethylene dimethyl ether preparation processes, and solves the technical problem of continuous production of polyoxymethylene dimethyl ether. A membrane separation element with precisely controlled pores in membrane is used to realize a direct separation of the feedstocks from the catalyst within the reactor, and effectively reduce the permeation resistance of the separation membrane tube. By oppositely switching the flowing direction of liquid reaction materials, the adhesion of the catalyst to the separation membrane tube is inhibited, and some particles stuck in separation membrane tube are removed, which ensures the continuous operation of the reaction process and allows a molecular sieve catalyst to exhibit its advantage of long catalytic life.

The present invention provides a production method of α-fluoroacrylate ester, a composition containing a highly-pure fluorocyclopropane derivative and a composition containing highly-pure α-fluoroacrylate ester. The present invention relates to a method of producing a compound represented by the following formula (F), including subjecting a composition containing a compound represented by the following formula (A) to a purification treatment in the order of distillation and washing with an aqueous alkali solution to give a purified product containing a compound represented by the following formula (A), and subjecting the purified product to a thermal decomposition reaction, a composition containing a highly-pure compound represented by the following formula (A), and a composition containing a highly-pure compound represented by the following formula (F), wherein R may be the same or different and is a monovalent hydrocarbon group, and X is a halogen atom: ##STR00001##

The present invention provides a production method of α-fluoroacrylate ester, a composition containing a highly-pure fluorocyclopropane derivative and a composition containing highly-pure α-fluoroacrylate ester. The present invention relates to a method of producing a compound represented by the following formula (F), including subjecting a composition containing a compound represented by the following formula (A) to a purification treatment in the order of distillation and washing with an aqueous alkali solution to give a purified product containing a compound represented by the following formula (A), and subjecting the purified product to a thermal decomposition reaction, a composition containing a highly-pure compound represented by the following formula (A), and a composition containing a highly-pure compound represented by the following formula (F), wherein R may be the same or different and is a monovalent hydrocarbon group, and X is a halogen atom: ##STR00001##

A method of producing dimethoxymethane oligomers (DMMn), the method comprising: reacting a formaldehyde source and dimethoxymethane monomer (DMM1) in the presence of an acidic catalyst to produce a reaction effluent comprising DMMn and unreacted DMM1; and separating, from the reaction effluent, DMM1-2 including unreacted DMM1 and DMMn having a chain length n equal to 2 (DMM2), dimethoxymethane oligomers having a chain length n in the range of from 2-5 (DMM2-5), dimethoxymethane oligomers having a chain length n of ≥5 (DMM5+), or a combination thereof, wherein the separating comprises distillation in the presence of at least one alcohol, a distillate fuel, or both.

A method of producing dimethoxymethane oligomers (DMMn), the method comprising: reacting a formaldehyde source and dimethoxymethane monomer (DMM1) in the presence of an acidic catalyst to produce a reaction effluent comprising DMMn and unreacted DMM1; and separating, from the reaction effluent, DMM1-2 including unreacted DMM1 and DMMn having a chain length n equal to 2 (DMM2), dimethoxymethane oligomers having a chain length n in the range of from 2-5 (DMM2-5), dimethoxymethane oligomers having a chain length n of ≥5 (DMM5+), or a combination thereof, wherein the separating comprises distillation in the presence of at least one alcohol, a distillate fuel, or both.

A method of producing dimethoxymethane oligomers (DMMn), the method comprising: reacting a formaldehyde source and dimethoxymethane monomer (DMM1) in the presence of an acidic catalyst to produce a reaction effluent comprising DMMn and unreacted DMM1; and separating, from the reaction effluent, DMM1-2 including unreacted DMM1 and DMMn having a chain length n equal to 2 (DMM2), dimethoxymethane oligomers having a chain length n in the range of from 2-5 (DMM2-5), dimethoxymethane oligomers having a chain length n of ≥5 (DMM5+), or a combination thereof, wherein the separating comprises distillation in the presence of at least one alcohol, a distillate fuel, or both.

The present invention relates to a cocrystal of ubiquinol and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

The present invention relates to a cocrystal of ubiquinol and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

The disclosure relates to a process for continuously producing polyoxymethylene dimethyl ethers at low temperature, pertains to the technical field of polyoxymethylene dimethyl ether preparation processes, and solves the technical problem of continuous production of polyoxymethylene dimethyl ether. A membrane separation element with precisely controlled pores in membrane is used to realize a direct separation of the feedstocks from the catalyst within the reactor, and effectively reduce the permeation resistance of the separation membrane tube. By oppositely switching the flowing direction of liquid reaction materials, the adhesion of the catalyst to the separation membrane tube is inhibited, and some particles stuck in separation membrane tube are removed, which ensures the continuous operation of the reaction process and allows a molecular sieve catalyst to exhibit its advantage of long catalytic life.

The disclosure relates to a process for continuously producing polyoxymethylene dimethyl ethers at low temperature, pertains to the technical field of polyoxymethylene dimethyl ether preparation processes, and solves the technical problem of continuous production of polyoxymethylene dimethyl ether. A membrane separation element with precisely controlled pores in membrane is used to realize a direct separation of the feedstocks from the catalyst within the reactor, and effectively reduce the permeation resistance of the separation membrane tube. By oppositely switching the flowing direction of liquid reaction materials, the adhesion of the catalyst to the separation membrane tube is inhibited, and some particles stuck in separation membrane tube are removed, which ensures the continuous operation of the reaction process and allows a molecular sieve catalyst to exhibit its advantage of long catalytic life.