A process for preparing a dienynal compound of the following general formula (2):
CH.sub.2═CHC≡CCH═CH(CH.sub.2).sub.nCHO  (2), wherein n represents an integer of 0 to 11, the process comprising a step of hydrolyzing a dialkoxyalkadienyne compound of the following general formula (1):
CH.sub.2═CHC≡CCH═CH(CH.sub.2).sub.nCH(OR.sup.1)(OR.sup.2)  (1) wherein R.sup.1 and R.sup.2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, preferably 1 to 8, more preferably 1 to 4, or R.sup.1 and R.sup.2 may be bonded to each other to form a divalent hydrocarbon group, R.sup.1-R.sup.2, having from 2 to 10 carbon atoms, and n represents an integer of 0 to 11, to obtain the dienynal compound (2). ##STR00001##

Hydroxyacetal or hydroxyketal monomers, processes for their preparation, their use to produce degradable polymers, hydroxy-functional intermediates resulting from degradation, and repurposed polymers made from the hydroxy-functional intermediates are described. The invention avoids the energy-intensive conditions normally used to degrade polyurethanes and generates new hydroxy-functional intermediates that can be repurposed or upcycled. Polyurethanes and melamines, materials once destined for a landfill, can have a second life. Incorporation of a photoacid generator into microcapsule core materials and fabrication of the shell from the hydroxy-functional acetal or ketal monomers promotes facile, inside-out, solid-state degradation of the microcapsule shell triggered by UV light and acid generation in a hydrophobic environment. This enables controlled release of flavors, fragrances, biocides, agricultural actives, or other oil-based beneficial agents from within the microcapsules.

The disclosure relates to a process for continuously producing polyoxymethylene dimethyl ethers at low temperature, pertains to the technical field of polyoxymethylene dimethyl ether preparation processes, and solves the technical problem of continuous production of polyoxymethylene dimethyl ether. A membrane separation element with precisely controlled pores in membrane is used to realize a direct separation of the feedstocks from the catalyst within the reactor, and effectively reduce the permeation resistance of the separation membrane tube. By oppositely switching the flowing direction of liquid reaction materials, the adhesion of the catalyst to the separation membrane tube is inhibited, and some particles stuck in separation membrane tube are removed, which ensures the continuous operation of the reaction process and allows a molecular sieve catalyst to exhibit its advantage of long catalytic life.

A process for preparing 4-penten-2-ynal of the following formula (2):
CH.sub.2═CHC≡CCHO  (2)
the process comprising a step of hydrolyzing a 5,5-dialkoxy-1-penten-3-yne compound of the following general formula (1):
CH.sub.2═CHC≡CCH(OR.sup.1)(OR.sup.2)  (1)
wherein R.sup.1 and R.sup.2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, preferably 1 to 8, more preferably 1 to 4, or R.sup.1 and R.sup.2 may be bonded to each other to form a divalent hydrocarbon group, R.sup.1-R.sup.2, having from 2 to 10 carbon atoms,
to obtain 4-penten-2-ynal (2). ##STR00001##

A process for preparing 4-penten-2-ynal of the following formula (2):
CH.sub.2═CHC≡CCHO  (2)
the process comprising a step of hydrolyzing a 5,5-dialkoxy-1-penten-3-yne compound of the following general formula (1):
CH.sub.2═CHC≡CCH(OR.sup.1)(OR.sup.2)  (1)
wherein R.sup.1 and R.sup.2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, preferably 1 to 8, more preferably 1 to 4, or R.sup.1 and R.sup.2 may be bonded to each other to form a divalent hydrocarbon group, R.sup.1-R.sup.2, having from 2 to 10 carbon atoms,
to obtain 4-penten-2-ynal (2). ##STR00001##

The present invention provide for preparing a formylalkenyl alkoxymethyl ether compound of the following general formula (2): R.sup.3CH.sub.2OCH.sub.2O(CH.sub.2).sub.aCH═CHCHO (2), wherein R.sup.3 represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group; and “a” represents an integer of 1 to 10, the process comprising: hydrolyzing a dialkoxyalkenyl alkoxymethyl ether compound of the following general formula (1): R.sup.3CH.sub.2OCH.sub.2O(CH.sub.2).sub.aCH═CHCH(OR.sup.1)(OR.sup.2) (1), wherein R.sup.1 and R.sup.2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, or R.sup.1 and R.sup.2 may form together a divalent hydrocarbon group, R.sup.1-R.sup.2, having 2 to 10 carbon atoms; and R.sup.3 and “a” are as defined above, in the presence of an acid while removing an alcohol compound thus generated to form the formylalkenyl alkoxymethyl ether compound (2).

The present invention provide for preparing a formylalkenyl alkoxymethyl ether compound of the following general formula (2): R.sup.3CH.sub.2OCH.sub.2O(CH.sub.2).sub.aCH═CHCHO (2), wherein R.sup.3 represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group; and “a” represents an integer of 1 to 10, the process comprising: hydrolyzing a dialkoxyalkenyl alkoxymethyl ether compound of the following general formula (1): R.sup.3CH.sub.2OCH.sub.2O(CH.sub.2).sub.aCH═CHCH(OR.sup.1)(OR.sup.2) (1), wherein R.sup.1 and R.sup.2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, or R.sup.1 and R.sup.2 may form together a divalent hydrocarbon group, R.sup.1-R.sup.2, having 2 to 10 carbon atoms; and R.sup.3 and “a” are as defined above, in the presence of an acid while removing an alcohol compound thus generated to form the formylalkenyl alkoxymethyl ether compound (2).

The present invention discloses a cobalt compound of formula (I), a process for the preparation and use thereof. The present invention further relates to a pharmaceutical composition and a method inhibition of Tau Aggregation in a subject in need thereof using compound of formula (I). ##STR00001##

The present invention discloses a cobalt compound of formula (I), a process for the preparation and use thereof. The present invention further relates to a pharmaceutical composition and a method inhibition of Tau Aggregation in a subject in need thereof using compound of formula (I). ##STR00001##

The present invention provides a process for preparing an alkoxymethyl alkynyl ether compound having a terminal triple bond of the following formula (4): H—C≡C(CH.sub.2).sub.aOCH.sub.2OCH.sub.2R (4), wherein R represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, and “a” represents an integer of 1 to 10, the method comprising subjecting an alkynol compound having a terminal triple bond of the following formula (1): H—C≡C(CH.sub.2).sub.aOH (1), wherein “a” is as defined above, to an alkoxymethylation with a halomethyl alkyl ether compound of the following formula (3): RCH.sub.2OCH.sub.2X (3), wherein X represents a halogen atom, and R is as defined above, in the presence of a dialkylaniline compound of the following formula (2): [CH.sub.3(CH.sub.2).sub.b][CH.sub.3(CH.sub.2).sub.c]NC.sub.6H.sub.5 (2), wherein b and c represent, independently of each other, an integer of 0 to 9, to form the alkoxymethyl alkynyl ether compound (4) having a terminal triple bond.