The present invention relates to a flavour mixture containing 2E,4Z,7Z- and 2E,4E,7Z-tridecatrienal. This flavour mixture can be produced advantageously from arachidonic acid or oils containing esters thereof.

The present invention relates to a flavour mixture containing 2E,4Z,7Z- and 2E,4E,7Z-tridecatrienal. This flavour mixture can be produced advantageously from arachidonic acid or oils containing esters thereof.

The present invention relates to a flavour mixture containing 2E,4Z,7Z- and 2E,4E,7Z-tridecatrienal. This flavour mixture can be produced advantageously from arachidonic acid or oils containing esters thereof.

Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

Disclosed is a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method includes the following steps: suspending a palladium compound and a metal hydride in a solvent under the protection of nitrogen, then adding an electron-deficient olefin compound, reacting same at 0° C.-100° C. for 0.3 to 10 hours, then adding a saturated ammonium chloride aqueous solution to stop the reaction, and then subjecting same to extraction, evaporation until dryness, and column chromatography purification to obtain the 1,3-dicarbonyl compound. The hydride and palladium compound catalysts used by the present invention are reagents easily obtained in a laboratory. Compared to a common hydrogen hydrogenation method, the method is easier to operate, and has a higher safety, mild conditions, and a high reaction yield.

Disclosed is a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method includes the following steps: suspending a palladium compound and a metal hydride in a solvent under the protection of nitrogen, then adding an electron-deficient olefin compound, reacting same at 0° C.-100° C. for 0.3 to 10 hours, then adding a saturated ammonium chloride aqueous solution to stop the reaction, and then subjecting same to extraction, evaporation until dryness, and column chromatography purification to obtain the 1,3-dicarbonyl compound. The hydride and palladium compound catalysts used by the present invention are reagents easily obtained in a laboratory. Compared to a common hydrogen hydrogenation method, the method is easier to operate, and has a higher safety, mild conditions, and a high reaction yield.

A method of synthesizing a substituted cyclopentadiene compound. The synthesis comprises a step of cyclizing, in the presence of a phosphorous pentoxide/methanesulfonic acid reagent, an alpha,beta-unsaturated carboxylic acid, cycloalkyl ester compound to make a substituted cyclopentenone compound, and converting the substituted cyclopentenone compound to the substituted cyclopentadiene compound. Also, a method of synthesizing a substituted metallocene compound comprising a metal-(substituted cyclopentadienyl ligand) complex, wherein the substituted cyclopentadienyl ligand is made from the substituted cyclopentadiene compound. A metal-(substituted cyclopentadienyl ligand) complex and substituted metallocene compound made by the method and a substituted metallocene catalyst made therefrom.

A method of synthesizing a substituted cyclopentadiene compound. The synthesis comprises a step of cyclizing, in the presence of a phosphorous pentoxide/methanesulfonic acid reagent, an alpha,beta-unsaturated carboxylic acid, cycloalkyl ester compound to make a substituted cyclopentenone compound, and converting the substituted cyclopentenone compound to the substituted cyclopentadiene compound. Also, a method of synthesizing a substituted metallocene compound comprising a metal-(substituted cyclopentadienyl ligand) complex, wherein the substituted cyclopentadienyl ligand is made from the substituted cyclopentadiene compound. A metal-(substituted cyclopentadienyl ligand) complex and substituted metallocene compound made by the method and a substituted metallocene catalyst made therefrom.

The present invention relates to compounds of formula (I): ##STR00001##
in which R1 is a hydrogen atom, a phenyl radical, or a straight or branched, saturated or unsaturated hydrocarbon radical having 1 to 8 carbon atoms.