Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ,-unsaturated or -bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ,-unsaturated or -bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ,-unsaturated or -bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ,-unsaturated or -bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.

The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.

The invention relates to compounds of Formula I or Formula II:

##STR00001## to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.

The invention relates to compounds of Formula I or Formula II:

##STR00001## to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.

Compounds that inhibit vesicle amine transport 1 (VAT1); compositions comprising the same; and their use for inhibiting metastasis in cancer.

Compounds that inhibit vesicle amine transport 1 (VAT1); compositions comprising the same; and their use for inhibiting metastasis in cancer.