Patent classifications
C07C49/35
Dimethylcyclobutanone compounds, dimethylcyclobutane compounds, and processes for preparing the same
The present invention provides a process for preparing a dimethylcyclobutane compound of the following general formula (1A), the process comprising reacting a dimethylcyclobutanone compound of the following general formula (2) with a phosphonic ester compound of the following general formula (3) to produce an unsaturated ester compound of the following general formula (4), having a dimethylcyclobutane ring, and subjecting the unsaturated ester compound (4), having a dimethylcyclobutane ring, to a reduction reaction to produce the dimethylcyclobutane compound (1A). ##STR00001##
USE OF SMALL MOLECULE INHIBITORS TO KLF10 FOR MODULATION OF T REGULATORY CELLS AND CANCER IMMUNOTHERAPY
The invention relates to compositions and methods for inhibiting Krppel-like Factor 10 (KLF10) for modulation of T regulatory cells and cancer immunotherapy.
C-GLYCOSIDE DERIVATIVE
The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof:
##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c and X are defined as in the description.
C-GLYCOSIDE DERIVATIVE
The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof:
##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c and X are defined as in the description.
C-glycoside derivatives
The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: ##STR00001##
wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c and X are defined as in the description.
SGLT2 INHIBITOR INTERMEDIATE V-1 AND USE THEREOF
SGLT2 inhibitor intermediate V-1 and the use thereof. The present invention specifically relates to an intermediate as represented by formula V-1 and the use thereof in the preparation of an SCLT2 inhibitor. The intermediate and a method for preparing an SCLT2 inhibitor have the advantages of easily available raw materials, simple operation, short production period, high yield and suitability for industrial production.
SGLT2 INHIBITOR INTERMEDIATE V-1 AND USE THEREOF
SGLT2 inhibitor intermediate V-1 and the use thereof. The present invention specifically relates to an intermediate as represented by formula V-1 and the use thereof in the preparation of an SCLT2 inhibitor. The intermediate and a method for preparing an SCLT2 inhibitor have the advantages of easily available raw materials, simple operation, short production period, high yield and suitability for industrial production.