The discovery of distinct modes of asymmetric catalysis has the potential to rapidly advance chemists' ability to build enantioenriched molecules. As an example, the use of chiral cation salts as phase-transfer catalysts for anionic reagents has enabled a vast set of enantioselective transformations. A largely overlooked analogous mechanism wherein a chiral anionic catalyst brings a cationic species into solution is itself a powerful method. The concept is broadly applicable to a number of different reaction pathways, including to the enantioselective fluorocyclization of olefins, and dearomatization of aromatic systems with a cationic electrophile-transferring (e.g., fluorinating) agent and a chiral phosphate catalyst. The reactions proceed in high yield and stereoselectivity. The compounds and methods of the invention are of particular value, especially considering the scarcity of alternative approaches.

Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ,-unsaturated or -bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ,-unsaturated or -bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ,-unsaturated or -bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ,-unsaturated or -bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ,-unsaturated or -bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ,-unsaturated or -bromo ketones or aldehydes in large scales to avoid using precious metal compounds.

Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ,-unsaturated or -bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ,-unsaturated or -bromo ketones or aldehydes in large scales to avoid using precious metal compounds.