Disclosed is a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method includes the following steps: suspending a palladium compound and a metal hydride in a solvent under the protection of nitrogen, then adding an electron-deficient olefin compound, reacting same at 0° C.-100° C. for 0.3 to 10 hours, then adding a saturated ammonium chloride aqueous solution to stop the reaction, and then subjecting same to extraction, evaporation until dryness, and column chromatography purification to obtain the 1,3-dicarbonyl compound. The hydride and palladium compound catalysts used by the present invention are reagents easily obtained in a laboratory. Compared to a common hydrogen hydrogenation method, the method is easier to operate, and has a higher safety, mild conditions, and a high reaction yield.

Compounds of formula (I) in the form of any one of its stereoisomers or a mixture thereof are provided, wherein the dotted lines represent a carbon-carbon single bond or a carbon-carbon double bond; and one R.sup.1 group represents a hydrogen atom and the second R.sup.1 group represents a methyl group. Also provided are their uses as perfuming ingredients to impart vetiver/rooty and powdery notes; e.g. in perfuming compositions or in consumer products.

##STR00001##

Compounds of formula (I) in the form of any one of its stereoisomers or a mixture thereof are provided, wherein the dotted lines represent a carbon-carbon single bond or a carbon-carbon double bond; and one R.sup.1 group represents a hydrogen atom and the second R.sup.1 group represents a methyl group. Also provided are their uses as perfuming ingredients to impart vetiver/rooty and powdery notes; e.g. in perfuming compositions or in consumer products.

##STR00001##

The present invention is directed to methods for the preparation of eremophila-1(10)-11(13)-dien-12,8-olide (EPD) and analogues thereof.

The present invention is directed to methods for the preparation of eremophila-1(10)-11(13)-dien-12,8-olide (EPD) and analogues thereof.

Provided is an application of a metal hydride/palladium compound system in the preparation of a 1,3-dicarbonyl compound in a cascade reaction of an electron-deficient alkene compound, said reaction comprising the following steps: under the protection of nitrogen, a palladium compound and a metal hydride are suspended and stirred in a solvent, then an electron-deficient alkene compound is added; the mixture reacts at 0 C. to 100 C. for 0.3 to 10 hours; a saturated ammonium chloride aqueous solution is added to stop the reaction, and then extraction, drying by evaporation and purification by column chromatography are performed to obtain the product of 1,3-dicarbonyl compound. The hydride and palladium compound catalysts used in the method are reagents easily obtained in a laboratory; compared with the commonly used methods of hydrogenation with hydrogen gas, the method can be easily operated, and has high safety, mild conditions and high reaction yield.

Disclosed is a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method includes the following steps: suspending a palladium compound and a metal hydride in a solvent under the protection of nitrogen, then adding an electron-deficient olefin compound, reacting same at 0 C.-100 C. for 0.3 to 10 hours, then adding a saturated ammonium chloride aqueous solution to stop the reaction, and then subjecting same to extraction, evaporation until dryness, and column chromatography purification to obtain the 1,3-dicarbonyl compound. The hydride and palladium compound catalysts used by the present invention are reagents easily obtained in a laboratory. Compared to a common hydrogen hydrogenation method, the method is easier to operate, and has a higher safety, mild conditions, and a high reaction yield.

The present invention relates to trans isomers of formula (I) ##STR00001## in the form of any one of its stereoisomers or a mixture thereof, and wherein the bold and hatched lines indicate a relative or absolute configuration; and one dotted line represents a carbon-carbon single bond and the other a carbon-carbon double bond; and their uses as perfuming ingredients (e.g. to impart vetiver/rooty notes), e.g. in consumer products.

The present invention relates to trans isomers of formula (I) ##STR00001## in the form of any one of its stereoisomers or a mixture thereof, and wherein the bold and hatched lines indicate a relative or absolute configuration; and one dotted line represents a carbon-carbon single bond and the other a carbon-carbon double bond; and their uses as perfuming ingredients (e.g. to impart vetiver/rooty notes), e.g. in consumer products.

The invention relates to compounds of Formula (I), (II), (III) or (IV), salts thereof, pharmaceutical compositions thereof, as well as methods of treating, curing or preventing HIV in subjects.