A compound of the formula (I) ##STR00001##
in which, independently, R.sub.1 is selected from H and methyl; R.sub.2 is selected from H, and methyl; R.sub.3 is selected from H, methyl and ethyl; R.sub.4 is selected from H, methyl and ethyl; or R.sub.3 and R.sub.4 together form a ring in which n is 1 or 2. The compounds have the characteristic desirable odour qualities of the Damascone molecules, but lack their disadvantageous skin sensitization effects.

A compound of the formula (I) ##STR00001##
in which, independently, R.sub.1 is selected from H and methyl; R.sub.2 is selected from H, and methyl; R.sub.3 is selected from H, methyl and ethyl; R.sub.4 is selected from H, methyl and ethyl; or R.sub.3 and R.sub.4 together form a ring in which n is 1 or 2. The compounds have the characteristic desirable odour qualities of the Damascone molecules, but lack their disadvantageous skin sensitization effects.

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical.

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical.

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical.

Provided herein are compositions and methods of treating liver cancer by novel anticancer agents.

A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I ##STR00001## (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalization reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.

A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I ##STR00001## (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalization reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.

A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I ##STR00001## (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalization reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.

A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I

##STR00001## (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalisation reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone.

The method affords an easier and more efficient method of preparation.