Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.

Disclosed herein are reaction compositions comprising an oxidation catalyst, a solvent, and a substrate that is dissolved in the solvent. The oxidation catalyst comprises a metal ion complexed with an -keto acid and a tridentate N,N,O-ligand. Also disclosed herein are methods for oxidizing a CH bond of a molecule, the methods comprising contacting the molecule with a metal complex comprising a metal ion complexed with a tridentate N,N,O-ligand in the presence of an -keto acid and a solvent. In some embodiments, the oxidation catalyst or metal complex is linked to a solid support.

Disclosed herein are reaction compositions comprising an oxidation catalyst, a solvent, and a substrate that is dissolved in the solvent. The oxidation catalyst comprises a metal ion complexed with an -keto acid and a tridentate N,N,O-ligand. Also disclosed herein are methods for oxidizing a CH bond of a molecule, the methods comprising contacting the molecule with a metal complex comprising a metal ion complexed with a tridentate N,N,O-ligand in the presence of an -keto acid and a solvent. In some embodiments, the oxidation catalyst or metal complex is linked to a solid support.

The present invention provides a novel process for producing 2,6,6-trimethyl-2-cyclohexene-1,4-dione (keto-isophorone) by catalytic oxidation of 3,5,5-trimethylcyclohexa-3-ene-1-one (-isophorone) with hydrogen peroxide as the oxidant. In particular, the novel process includes phase transfer reagent in a biphasic system including an organic phase and an aqueous phase wherein the biphasic system includes 1) a tungsten polyoxyometallate as catalyst and hydrogen peroxide, and/or 2) a mixture of a) a mineral acid, b) hydrogen peroxide, and c) a metal tungstate.

The present invention provides a novel process for producing 2,6,6-trimethyl-2-cyclohexene-1,4-dione (keto-isophorone) by catalytic oxidation of 3,5,5-trimethylcyclohexa-3-ene-1-one (-isophorone) with hydrogen peroxide as the oxidant. In particular, the novel process includes phase transfer reagent in a biphasic system including an organic phase and an aqueous phase wherein the biphasic system includes 1) a tungsten polyoxyometallate as catalyst and hydrogen peroxide, and/or 2) a mixture of a) a mineral acid, b) hydrogen peroxide, and c) a metal tungstate.

The present invention relates to use of 2,3,6-Trimethyl-2-cyclohexen-1-one as aroma Ingredient. 2,3,6-Trimethyl-2-cyclohexen-1-one is used to impart an aroma impression which is reminiscent of animalic note, woody note, floral note, green note, minty note, dusty note, phenolic note, and/or camphoraceous note to a composition and also enhancing and/or modifying the aroma of a composition. The present invention is further directed to an aroma composition comprising 2,3,6-Trimethyl-2-cyclohexen-1-one and (i) at least one aroma chemical different from the 2,3,6-Trimethyl-2-cyclohexen-1-one or (ii) at least one non-aroma chemical carrier, or (iii) both (i) and (ii).

The present invention relates to use of 2,3,6-Trimethyl-2-cyclohexen-1-one as aroma Ingredient. 2,3,6-Trimethyl-2-cyclohexen-1-one is used to impart an aroma impression which is reminiscent of animalic note, woody note, floral note, green note, minty note, dusty note, phenolic note, and/or camphoraceous note to a composition and also enhancing and/or modifying the aroma of a composition. The present invention is further directed to an aroma composition comprising 2,3,6-Trimethyl-2-cyclohexen-1-one and (i) at least one aroma chemical different from the 2,3,6-Trimethyl-2-cyclohexen-1-one or (ii) at least one non-aroma chemical carrier, or (iii) both (i) and (ii).

A compound of Formula (I) ##STR00001##
or of a mixture comprising two, three, four, five, six or a plurality of different compounds of Formula (I) for the superadditive enhancement of an olfactory impression. The invention also relates to novel fragrance and/or flavor material compositions which, in addition to a compound of Formula (I) or a mixture thereof, further contains one, two, three or a plurality of further fragrance and/or flavor materials, the fragrance and/or flavor material or the further fragrance and/or flavor materials not being compound of Formula (I).

A compound of Formula (I) ##STR00001##
or of a mixture comprising two, three, four, five, six or a plurality of different compounds of Formula (I) for the superadditive enhancement of an olfactory impression. The invention also relates to novel fragrance and/or flavor material compositions which, in addition to a compound of Formula (I) or a mixture thereof, further contains one, two, three or a plurality of further fragrance and/or flavor materials, the fragrance and/or flavor material or the further fragrance and/or flavor materials not being compound of Formula (I).

The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.