A process for the preparation of a compound of formula (I) wherein R.sub.1 is hydrogen, fluoro or chloro; which process comprises: a) reacting a compound of formula (II) wherein R.sub.1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III) wherein R.sub.1 is hydrogen, fluoro or chloro; b) reacting the compound of formula (III) with trichloroisocyanuric acid in the presence of sulfuric acid or fuming sulfuric acid to the compound of formula (IV) wherein R1 is hydrogen, fluoro or chloro; and c) reacting the compound of formula (III) with chlorine gas at a temperature from 180° C. to 250° C. to the compound of formula (I).

##STR00001##

A process for the preparation of a compound of formula (I) wherein R.sub.1 is hydrogen, fluoro or chloro; which process comprises: a) reacting a compound of formula (II) wherein R.sub.1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III) wherein R.sub.1 is hydrogen, fluoro or chloro; b) reacting the compound of formula (III) with trichloroisocyanuric acid in the presence of sulfuric acid or fuming sulfuric acid to the compound of formula (IV) wherein R1 is hydrogen, fluoro or chloro; and c) reacting the compound of formula (III) with chlorine gas at a temperature from 180° C. to 250° C. to the compound of formula (I).

##STR00001##

The invention relates to a process for the preparation of a compound of formula I (I), wherein R.sub.1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R.sub.1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R.sub.1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to the compound of formula I.

##STR00001##

The invention relates to a process for the preparation of a compound of formula I (I), wherein R.sub.1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R.sub.1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R.sub.1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to the compound of formula I.

##STR00001##

A composition, consisting essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-V donor. The molar ratio of copper to the fluoroalkyl group is approximately 1.

A composition, consisting essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-V donor. The molar ratio of copper to the fluoroalkyl group is approximately 1.

The present disclosure provides processes for the preparation of a compound of formula: ##STR00001##
which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

The present disclosure provides processes for the preparation of a compound of formula: ##STR00001##
which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

The invention relates to a process for preparing a compound of (III) ##STR00001## wherein X is a leaving group; and R.sup.1 is C.sub.1-C.sub.6 alkyl;
which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof ##STR00002## Compounds of formula (III) are key intermediates in the synthesis of Bilastine.

The invention relates to a process for preparing a compound of (III) ##STR00001## wherein X is a leaving group; and R.sup.1 is C.sub.1-C.sub.6 alkyl;
which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof ##STR00002## Compounds of formula (III) are key intermediates in the synthesis of Bilastine.