Provided is a metal salt of an alicyclic dicarboxylic acid with excellent dispersibility in polyolefin resins, and excellent crystallinity improving effect that is essential as a crystal nucleating agent for polyolefin resins, regardless of processing conditions. A method is also provided for producing the metal salt of an alicyclic dicarboxylic acid; a crystal nucleating agent containing the metal salt of an alicyclic dicarboxylic acid; a crystal nucleating agent composition for polyolefin resins containing the crystal nucleating agent and a fatty acid metal salt; a polyolefin resin composition containing the crystal nucleating agent; and a polyolefin resin molded article obtained using the polyolefin resin composition. Provided is a metal salt of an alicyclic dicarboxylic acid in which the alicyclic dicarboxylic acid is an alkyl substituent-containing cyclohexane-1,2-dicarboxylic acid, and the metal salt is a calcium salt, a hydroxyaluminum salt, a disodium salt, or a dilithium salt.

The invention relates to a process for obtaining a formate from a reaction mixture (10) in which a polyoxometallate ion, which acts as a catalyst, is in contact with an organic material at a temperature below 120° C. to produce formic acid in an aqueous solution, with the following steps. a) separating a mixture of formic acid and water from the reaction mixture by reverse osmosis and/or as vapor (18), the vapor (18) subsequently being condensed, and b) reacting the formic acid with a hydroxide (24) in aqueous solution to produce a solution of a formate.

The invention relates to a process for obtaining a formate from a reaction mixture (10) in which a polyoxometallate ion, which acts as a catalyst, is in contact with an organic material at a temperature below 120° C. to produce formic acid in an aqueous solution, with the following steps. a) separating a mixture of formic acid and water from the reaction mixture by reverse osmosis and/or as vapor (18), the vapor (18) subsequently being condensed, and b) reacting the formic acid with a hydroxide (24) in aqueous solution to produce a solution of a formate.

The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.

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The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.

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The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

The present invention relates to particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, to a process of making said particles, to pharmaceutical compositions comprising said particles and to method of treating cancers using said pharmaceutical compositions.

The subject invention provides pridopidine L-tartrate, compositions and a process for manufacture thereof.

The subject invention provides pridopidine L-tartrate, compositions and a process for manufacture thereof.

The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R.sup.10 is a linear or branched C.sub.1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.