Provided is a method for producing a composition containing gallic acid, the composition having a low content rate of protocatechuic acid using a microbial culture solution. A method for producing a composition containing gallic acid, the method comprising a step (A) of performing cooling crystallization using an aqueous solution (a) containing gallic acid and protocatechuic acid at 0.9° C./min or less.

Provided is a method for producing a composition containing gallic acid, the composition having a low content rate of protocatechuic acid using a microbial culture solution. A method for producing a composition containing gallic acid, the method comprising a step (A) of performing cooling crystallization using an aqueous solution (a) containing gallic acid and protocatechuic acid at 0.9° C./min or less.

Systems and methods for extracting a compound of interest from plant material, such as a cannabidiol (CBD) from cannabis, are provided. Particularly, the disclosed systems and methods utilize a crude oil to separate water and impurities including fats, sugars, resin glues, chlorophyll, and proteins prior to preparation of a CBD distillate. The systems and methods are operable to remove the impurities from the crude oil with a brine solution and at least one acid prior to distillation. The systems and methods are operable with conventional solvents containing between about 5 wt % and about 8 wt % water.

Systems and methods for extracting a compound of interest from plant material, such as a cannabidiol (CBD) from cannabis, are provided. Particularly, the disclosed systems and methods utilize a crude oil to separate water and impurities including fats, sugars, resin glues, chlorophyll, and proteins prior to preparation of a CBD distillate. The systems and methods are operable to remove the impurities from the crude oil with a brine solution and at least one acid prior to distillation. The systems and methods are operable with conventional solvents containing between about 5 wt % and about 8 wt % water.

A method of production of malic acid includes treating a first intermediate product to form a second intermediate product. The treating includes substantially removing impurities from the first intermediate product to obtain a treated intermediate product by gas stripping the crude maleic anhydride, or subjecting a mixture of one or more of the crude maleic acid, the crude fumaric acid, and the vent gas scrubber solution obtained from a phthalic anhydride production process or a maleic anhydride production process to crystallization, passing an aqueous solution of the treated intermediate product through a carbon column to substantially remove retained impurities to form the second intermediate product, obtaining a feed that includes the second intermediate product, and causing the feed to undergo hydration reaction in a tubular reactor or a continuous stirred tank reactor to produce malic acid.

A method of production of malic acid includes treating a first intermediate product to form a second intermediate product. The treating includes substantially removing impurities from the first intermediate product to obtain a treated intermediate product by gas stripping the crude maleic anhydride, or subjecting a mixture of one or more of the crude maleic acid, the crude fumaric acid, and the vent gas scrubber solution obtained from a phthalic anhydride production process or a maleic anhydride production process to crystallization, passing an aqueous solution of the treated intermediate product through a carbon column to substantially remove retained impurities to form the second intermediate product, obtaining a feed that includes the second intermediate product, and causing the feed to undergo hydration reaction in a tubular reactor or a continuous stirred tank reactor to produce malic acid.

The presented invention relates to crystalline Form A and Form B of Bempedoic acid, a process for preparation thereof and a composition comprising the Form A or Form B.

The presented invention relates to crystalline Form A and Form B of Bempedoic acid, a process for preparation thereof and a composition comprising the Form A or Form B.

The presented invention relates to crystalline Form A and Form B of Bempedoic acid, a process for preparation thereof and a composition comprising the Form A or Form B.

Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7 hydrocarbon solvents, adding thereto a selected amine to thereby precipitate a CBDA-amine salt therefrom, dissolving the recovered CBDA-amine salt in a selected solvent and then adding thereto a selected antisolvent to thereby recrystallize a purified CBDA-amine salt therefrom. The recrystallized CBDA-amine salt may be decarboxylated to form a mixture of cannabidiol (CBD) and amine. The CBD amine mixture may be acidified to separate the amine from CBD. Also disclosed are CBDA-amine salts produced with certain amines selected from groups of secondary amines, tertiary amines, diamines, amino alcohols, amino ethers, and highly basic amines.