Patent classifications
A01N57/18
Methods for Making L-Glufosinate
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
Methods for the Inhibition and Dispersal of Biofilms
The present disclosure relates to methods for inhibiting microbial growth, inhibiting biofilm formation or development, disrupting existing biofilms, reducing the biomass of a biofilm, and methods for sensitizing a biofilm and microorganisms with the biofilm to an antimicrobial agent.
Methods for the Inhibition and Dispersal of Biofilms
The present disclosure relates to methods for inhibiting microbial growth, inhibiting biofilm formation or development, disrupting existing biofilms, reducing the biomass of a biofilm, and methods for sensitizing a biofilm and microorganisms with the biofilm to an antimicrobial agent.
Methods for the Inhibition and Dispersal of Biofilms
The present disclosure relates to methods for inhibiting microbial growth, inhibiting biofilm formation or development, disrupting existing biofilms, reducing the biomass of a biofilm, and methods for sensitizing a biofilm and microorganisms with the biofilm to an antimicrobial agent.
Methods for making L-glufosinate
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
Methods for making L-glufosinate
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
Stable, concentrated herbicidal compositions
A liquid herbicidal composition is provided, comprising: a. 20 to 35 percent by weight, based on the total weight of the composition, of a water-soluble herbicidal ingredient; b. a C.sub.12-C.sub.16 alkyl ether sulfate; c. an organic solvent; and d. an alkyl polyglucoside.
The composition is stable; i.e., it occurs in a substantially continuous, single phase at temperatures as low as 20 C. It also has a viscosity of no more than 2000 cps at temperatures as low as 0 C.
Alkoxylated alkylamine quaternary surfactants for glyphosate
The present invention relates to stable glyphosate formulations with improved efficacy by a highly effective alkoxylated alkylamine quaternary surfactant at a very low used level. The alkoxylated alkylamine quaternary surfactant is compatible in all salts of glyphosate formulations (including potassium and ammonium) even at very high concentration (470-600 g a.e./l).
Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) ##STR00001## where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).
Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) ##STR00001## where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).