C07C53/128

NOVEL ANALOGS OF VALPROIC ACID AND METHODS OF MEDICAL TREATMENT USING THE SAME
20250066282 · 2025-02-27 ·

The present invention relates to compounds of Formula I wherein R1 is either H or D and wherein D is deuterium, or a pharmaceutically acceptable salt thereof. The present invention also relates to methods of treating abnormal conditions associated with excess fibrin deposition, thrombus formation, migraine headaches, bipolar disorders, epilepsy and associated conditions in which inhibition of histone deacetylase (HDAC) provides a therapeutic benefit.

##STR00001##

Carbonyl compounds, methods for preparing same and uses thereof

The present application relates to a compound of the following formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent independently of each other H or a (C.sub.1-C.sub.30) alkyl group, the total sum of the number of carbon atoms of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 being equal to 6+4x, x being a whole number of between 1 and 6, provided that: at most two of the groups R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, R.sup.5 represents H, OR, or NRR R, R and R, identical or different, represent H, a (C1-C10) alkyl group, at least one of groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 comprises or is a tertiobutyl group. (I) the method for preparing same and the uses thereof as a plasticising lubricant, surfactant or in a cosmetic composition.

Carbonyl compounds, methods for preparing same and uses thereof

The present application relates to a compound of the following formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent independently of each other H or a (C.sub.1-C.sub.30) alkyl group, the total sum of the number of carbon atoms of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 being equal to 6+4x, x being a whole number of between 1 and 6, provided that: at most two of the groups R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, R.sup.5 represents H, OR, or NRR R, R and R, identical or different, represent H, a (C1-C10) alkyl group, at least one of groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 comprises or is a tertiobutyl group. (I) the method for preparing same and the uses thereof as a plasticising lubricant, surfactant or in a cosmetic composition.

ZINC CARBOXYLATE SALT FOR PRODUCTION OF SEMICONDUCTOR NANOPARTICLE

A zinc carboxylate salt used in production of a semiconductor nanoparticle, in which a ratio of carboxylic acids having 8 to 10 carbon atoms in whole of carboxylic acids that form the zinc carboxylate salt is 80.0% by mass or more, and an average branching degree of the whole of the carboxylic acids that form the zinc carboxylate salt is in the range of 1.1 to 2.9. The present invention can provide a zinc salt used for easily producing a semiconductor nanoparticle having a core/shell type structure that has excellent optical properties in the case where two or more types of shell precursors are used to produce the semiconductor nanoparticle having a core/shell type structure.

ZINC CARBOXYLATE SALT FOR PRODUCTION OF SEMICONDUCTOR NANOPARTICLE

A zinc carboxylate salt used in production of a semiconductor nanoparticle, in which a ratio of carboxylic acids having 8 to 10 carbon atoms in whole of carboxylic acids that form the zinc carboxylate salt is 80.0% by mass or more, and an average branching degree of the whole of the carboxylic acids that form the zinc carboxylate salt is in the range of 1.1 to 2.9. The present invention can provide a zinc salt used for easily producing a semiconductor nanoparticle having a core/shell type structure that has excellent optical properties in the case where two or more types of shell precursors are used to produce the semiconductor nanoparticle having a core/shell type structure.

3,5,5-TRIMETHYLHEXANOIC ACID COMPOSITION, METHOD FOR PRODUCING THE COMPOSITION AND METHOD FOR IMPROVING SULFURIC ACID COLORING OF THE COMPOSITION

A 3,5,5-trimethylhexanoic acid composition containing 3,5,5-trimethylhexanoic acid and t-butyl alcohol in which the t-butyl alcohol concentration in terms of toluene-d8 measured by gas chromatography-olfactometry/mass spectrometry under the conditions below exceeds 0 ppb by volume and is 200 ppb by volume or less is provided. The composition is excellent in sulfuric acid coloring evaluation,

(Measurement Conditions) The 3,5,5-trimethylhexanoic acid composition is concentrated, and The concentrated sample is measured by gas chromatography-olfactometry using a column using dimethylpolysiloxane as a stationary phase, and the structure of a measured component is analyzed with a mass spectrometry detector.

3,5,5-TRIMETHYLHEXANOIC ACID COMPOSITION, METHOD FOR PRODUCING THE COMPOSITION AND METHOD FOR IMPROVING SULFURIC ACID COLORING OF THE COMPOSITION

A 3,5,5-trimethylhexanoic acid composition containing 3,5,5-trimethylhexanoic acid and t-butyl alcohol in which the t-butyl alcohol concentration in terms of toluene-d8 measured by gas chromatography-olfactometry/mass spectrometry under the conditions below exceeds 0 ppb by volume and is 200 ppb by volume or less is provided. The composition is excellent in sulfuric acid coloring evaluation,

(Measurement Conditions) The 3,5,5-trimethylhexanoic acid composition is concentrated, and The concentrated sample is measured by gas chromatography-olfactometry using a column using dimethylpolysiloxane as a stationary phase, and the structure of a measured component is analyzed with a mass spectrometry detector.

FATTY ACID COMPOUNDS

Disclosed herein are furan fatty acid synthetic compounds and furan fatty acidamino acid conjugates.

FATTY ACID COMPOUNDS

Disclosed herein are furan fatty acid synthetic compounds and furan fatty acidamino acid conjugates.

METHOD FOR CO-PRODUCING VALPROAMIDE AND SODIUM VALPROATE
20250346555 · 2025-11-13 ·

A process for preparing valpromide of formula I and sodium valproate of formula II which comprises: cyanoacetate and 1-chloropropane are subjected to composite catalytic dipropylation in the presence of alkali to obtain 2-cyano-2-valproate of formula III; 2-cyano-2-valproate is hydrolyzed and deacidified to give propylvaleronitrile of formula V; propylvaleronitrile is alcoholized in the presence of acid to give valpromide of formula I and valproate ester of formula VI; and valproate ester is hydrolyzed in a sodium hydroxide solution to afford sodium valproate of formula II.