Provided is a method for industrially advantageously producing a fluorinated hydrocarbon (3). The disclosed method for producing a fluorinated hydrocarbon represented by formula (3) includes bringing into contact, in a hydrocarbon-based solvent, a secondary or tertiary ether compound represented by formula (1) below with an acid fluoride represented by formula (2) in the presence of lithium salt or sodium salt (in the formulae, R.sup.1 and R.sup.2 each represent a C.sub.1-3 alkyl, and R.sup.1 and R.sup.2 may be bonded to each other to form a ring structure; R.sup.3 represents a hydrogen atom, methyl, or ethyl; and R.sup.4 and R.sup.5 each represent methyl or ethyl). ##STR00001##

Provided is a method for industrially advantageously producing a fluorinated hydrocarbon (3). The disclosed method for producing a fluorinated hydrocarbon represented by formula (3) includes bringing into contact, in a hydrocarbon-based solvent, a secondary or tertiary ether compound represented by formula (1) below with an acid fluoride represented by formula (2) in the presence of lithium salt or sodium salt (in the formulae, R.sup.1 and R.sup.2 each represent a C.sub.1-3 alkyl, and R.sup.1 and R.sup.2 may be bonded to each other to form a ring structure; R.sup.3 represents a hydrogen atom, methyl, or ethyl; and R.sup.4 and R.sup.5 each represent methyl or ethyl). ##STR00001##

Provided is a method for industrially advantageously producing a fluorinated hydrocarbon (3). The disclosed method for producing a fluorinated hydrocarbon represented by formula (3) includes bringing into contact, in a hydrocarbon-based solvent, a secondary or tertiary ether compound represented by formula (1) below with an acid fluoride represented by formula (2) in the presence of lithium salt or sodium salt (in the formulae, R.sup.1 and R.sup.2 each represent a C.sub.1-3 alkyl, and R.sup.1 and R.sup.2 may be bonded to each other to form a ring structure; R.sup.3 represents a hydrogen atom, methyl, or ethyl; and R.sup.4 and R.sup.5 each represent methyl or ethyl).

##STR00001##

Provided is a method for industrially advantageously producing a fluorinated hydrocarbon (3). The disclosed method for producing a fluorinated hydrocarbon represented by formula (3) includes bringing into contact, in a hydrocarbon-based solvent, a secondary or tertiary ether compound represented by formula (1) below with an acid fluoride represented by formula (2) in the presence of lithium salt or sodium salt (in the formulae, R.sup.1 and R.sup.2 each represent a C.sub.1-3 alkyl, and R.sup.1 and R.sup.2 may be bonded to each other to form a ring structure; R.sup.3 represents a hydrogen atom, methyl, or ethyl; and R.sup.4 and R.sup.5 each represent methyl or ethyl).

##STR00001##

Methods, compositions, and systems related to preparing gaseous .sup.18F-compounds for use in radiolabeling positron emission tomography (PET) tracer precursor compounds are disclosed. [.sup.18F]fluoride ions produced by conventional methods are converted by reaction with an acid anhydride having the formula: ##STR00001##
to a gaseous .sup.18F-compound having the formula: ##STR00002##
wherein each R is independently a substituted or unsubstituted, straight chain or branched C.sub.1-C.sub.4 alkyl group. The gaseous .sup.18F-compounds, which also can be readily trapped on solid-phase extraction media or in organic solvents such as acetonitrile, provide an alternative source of [.sup.18F]fluoride for use in the nucleophilic substitution reactions that are used to synthesize a large number of .sup.18F-labeled PET imaging tracers, including 2-[.sup.18F]fluoro-2-deoxyglucose (FDG).

Methods, compositions, and systems related to preparing gaseous .sup.18F-compounds for use in radiolabeling positron emission tomography (PET) tracer precursor compounds are disclosed. [.sup.18F]fluoride ions produced by conventional methods are converted by reaction with an acid anhydride having the formula: ##STR00001##
to a gaseous .sup.18F-compound having the formula: ##STR00002##
wherein each R is independently a substituted or unsubstituted, straight chain or branched C.sub.1-C.sub.4 alkyl group. The gaseous .sup.18F-compounds, which also can be readily trapped on solid-phase extraction media or in organic solvents such as acetonitrile, provide an alternative source of [.sup.18F]fluoride for use in the nucleophilic substitution reactions that are used to synthesize a large number of .sup.18F-labeled PET imaging tracers, including 2-[.sup.18F]fluoro-2-deoxyglucose (FDG).

Methods, compositions, and systems related to preparing gaseous .sup.18F-compounds for use in radiolabeling positron emission tomography (PET) tracer precursor compounds are disclosed. [.sup.18F]fluoride ions produced by conventional methods are converted by reaction with an acid anhydride having the formula: to a gaseous .sup.18F-compound having the formula: wherein each R is independently a substituted or unsubstituted, straight chain or branched CrC4 alkyl group. The resulting gaseous .sup.18F-compounds can be produced and stored in close proximity to the production location of the [.sup.18F]fluoride ions (such as within a cyclotron vault), or easily and efficiently transported long distances with minimal loss of-radioactivity. The gaseous .sup.18F-compounds, which also can be readily trapped on solid-phase extraction media or in organic solvents such as acetonitrile, provide an alternative source of [.sup.18F]fluoride for use in the nucleophilic substitution reactions that are used to synthesize a large number of .sup.18F-labeled PET imaging tracers, including 2-[.sup.18F]fluoro-2-deoxyglucose (FDG).

##STR00001##

Methods, compositions, and systems related to preparing gaseous .sup.18F-compounds for use in radiolabeling positron emission tomography (PET) tracer precursor compounds are disclosed. [.sup.18F]fluoride ions produced by conventional methods are converted by reaction with an acid anhydride having the formula: to a gaseous .sup.18F-compound having the formula: wherein each R is independently a substituted or unsubstituted, straight chain or branched CrC4 alkyl group. The resulting gaseous .sup.18F-compounds can be produced and stored in close proximity to the production location of the [.sup.18F]fluoride ions (such as within a cyclotron vault), or easily and efficiently transported long distances with minimal loss of-radioactivity. The gaseous .sup.18F-compounds, which also can be readily trapped on solid-phase extraction media or in organic solvents such as acetonitrile, provide an alternative source of [.sup.18F]fluoride for use in the nucleophilic substitution reactions that are used to synthesize a large number of .sup.18F-labeled PET imaging tracers, including 2-[.sup.18F]fluoro-2-deoxyglucose (FDG).

##STR00001##