Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm.sup.2×days] of the contact surface area [cm.sup.2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.

Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm.sup.2×days] of the contact surface area [cm.sup.2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.

The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.

The present invention is directed to a process for obtaining a lipid from a composition comprising microbial cells, the process comprising: treating the composition comprising microbial cells to a temperature of about 60° C. to about 95° C. at a pH of about 9 to about 11; separating the treated microbial cells into a light phase and a heavy phase; sequentially, in one or more cycles, raising the pH of the concentrated microbial cell composition to 10 or above, followed by lowering the pH of the concentrated microbial cell composition to a pH of less than 6 to lyse the concentrated microbial cell composition, wherein the raising and lowering of the pH also demulsifies the concentrated microbial cell composition; separating the lipid from the demulsified cell composition, and recovering the lipid.

The present invention is directed to a process for obtaining a lipid from a composition comprising microbial cells, the process comprising: treating the composition comprising microbial cells to a temperature of about 60° C. to about 95° C. at a pH of about 9 to about 11; separating the treated microbial cells into a light phase and a heavy phase; sequentially, in one or more cycles, raising the pH of the concentrated microbial cell composition to 10 or above, followed by lowering the pH of the concentrated microbial cell composition to a pH of less than 6 to lyse the concentrated microbial cell composition, wherein the raising and lowering of the pH also demulsifies the concentrated microbial cell composition; separating the lipid from the demulsified cell composition, and recovering the lipid.

Described herein are methods of preparing compounds derived from triglycerides or condensation polymers such as polyesters and/or polyamides. The methods may include subjecting triglyceride or condensation polymer containing matter to mechanical processing in the presence of a nucleophile.

Described herein are methods of preparing compounds derived from triglycerides or condensation polymers such as polyesters and/or polyamides. The methods may include subjecting triglyceride or condensation polymer containing matter to mechanical processing in the presence of a nucleophile.

The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX or Formula X and, the methods for the treatment of fungal infections may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of fungal infections.

Disclosed are methods or processes of synthesizing building blocks and feedstocks for producing a broader range of polymers, including renewable polymers, from renewable resources such as CO.sub.2. In a process of manufacturing a renewable feedstock for polymer production, a CO.sub.2 derived lactone is prepared and processed to form the renewable feedstock. The process may include alkoxycarbonylation of the CO.sub.2 derived lactone to form a diester and hydrogenation of the diester.

Disclosed are methods or processes of synthesizing building blocks and feedstocks for producing a broader range of polymers, including renewable polymers, from renewable resources such as CO.sub.2. In a process of manufacturing a renewable feedstock for polymer production, a CO.sub.2 derived lactone is prepared and processed to form the renewable feedstock. The process may include alkoxycarbonylation of the CO.sub.2 derived lactone to form a diester and hydrogenation of the diester.