The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

A method to make an improved organic photoconductor drum of an electrophotographic image forming device is provided. The improved organic photoconductor drum is prepared using a curable composition including a charge transport molecule containing four radical polymerizable functional groups of the general structure exemplified below:

##STR00001##

where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are selected from the group consisting of a radical polymerizable functional group, a non-radical polymerizable functional group, and one each of a radical polymerizable functional group and a non-radial polymerizable functional group, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group.

The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.

The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.

The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, NH.sub.2, NH(C.sub.1-C.sub.6 alkyl), N(C.sub.1-C.sub.6 alkyl).sub.2, OH, C.sub.1-C.sub.6 alkoxy, and C.sub.1-C.sub.6 haloalkoxy; X is a bond, CH.sub.2, CHR.sup.5, CCHR.sup.4, NR.sup.4, NOR.sup.4, O, S, SO, SO.sub.2, C(O), or C(NR.sup.4), or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each R.sup.4 is independently hydrogen or C.sub.1-6 alkyl; R.sup.5 is independently hydrogen, C.sub.1-6 alkyl, or OR.sup.6, where R.sup.6 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyL C.sub.3-12 cycloalkyl, heterocyclyl, aryl, arylC.sub.1-6 alkyl, heteroaryl, or heteroarylC.sub.1-6 alkyl; Y is C.sub.1-6 alkylene, C.sub.2-6 alkenylene, or C.sub.2-6 alkylylene moiety. ##STR00001##

The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, NH.sub.2, NH(C.sub.1-C.sub.6 alkyl), N(C.sub.1-C.sub.6 alkyl).sub.2, OH, C.sub.1-C.sub.6 alkoxy, and C.sub.1-C.sub.6 haloalkoxy; X is a bond, CH.sub.2, CHR.sup.5, CCHR.sup.4, NR.sup.4, NOR.sup.4, O, S, SO, SO.sub.2, C(O), or C(NR.sup.4), or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each R.sup.4 is independently hydrogen or C.sub.1-6 alkyl; R.sup.5 is independently hydrogen, C.sub.1-6 alkyl, or OR.sup.6, where R.sup.6 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyL C.sub.3-12 cycloalkyl, heterocyclyl, aryl, arylC.sub.1-6 alkyl, heteroaryl, or heteroarylC.sub.1-6 alkyl; Y is C.sub.1-6 alkylene, C.sub.2-6 alkenylene, or C.sub.2-6 alkylylene moiety. ##STR00001##

A method to make an improved organic photoconductor drum of an electrophotographic image forming device is provided. The improved organic photoconductor drum is prepared using a curable composition including a charge transport molecule containing four radical polymerizable functional groups of the general structure exemplified below: ##STR00001##
where R.sub.1 and R.sub.2 contain a spacer group and a radical polymerizable functional group, R.sub.3 and R.sub.4 are selected from the group consisting of a radical polymerizable functional group, a non-radical polymerizable functional group, and one each of a radical polymerizable functional group and a non-radial polymerizable functional group, and R.sub.5 and R.sub.6 contain a spacer group and a radical polymerizable functional group.