A process for the manufacturing of fire suppressing crystals having a high Q-factor particle size distribution, said fire suppression crystals being intended for use as a fire suppressing additive in polymer compositions, the process comprising the steps; a) Preparing a mother liquor comprising water and a salt composition obtained in step c) or d), the temperature of said mother liquor being adjusted to 10-50 C. and comprising said salt composition to a level of at least 90% of saturation. Calcium hydroxide is added to the mother liquor to a level of at least 90% of saturation. b) Preparing an acid solution comprising water and two or more acids selected from the group consisting of; C.sub.2-C.sub.6 mono-, di- and/or tri-carboxylic acids, and optionally a phosphorous compound. The temperature of said acid solution is adjusted to 20-90 C. 31 and comprising acids to a level of at least 50% of saturation. c) The mother liquor, comprising calcium hydroxide, obtained from step a) is subjected to intense agitation under which the acid solution obtained from step b) is slowly added to said mother liquor allowing reaction to form salt until supersaturation is achieved while maintaining PH at a level securing that no unreacted acids remains after reaction, d) Crystals formed in the reaction of step c) is continuously or discontinuously removed from the reaction product of step c).

A process for the manufacturing of fire suppressing crystals having a high Q-factor particle size distribution, said fire suppression crystals being intended for use as a fire suppressing additive in polymer compositions, the process comprising the steps; a) Preparing a mother liquor comprising water and a salt composition obtained in step c) or d), the temperature of said mother liquor being adjusted to 10-50 C. and comprising said salt composition to a level of at least 90% of saturation. Calcium hydroxide is added to the mother liquor to a level of at least 90% of saturation. b) Preparing an acid solution comprising water and two or more acids selected from the group consisting of; C.sub.2-C.sub.6 mono-, di- and/or tri-carboxylic acids, and optionally a phosphorous compound. The temperature of said acid solution is adjusted to 20-90 C. 31 and comprising acids to a level of at least 50% of saturation. c) The mother liquor, comprising calcium hydroxide, obtained from step a) is subjected to intense agitation under which the acid solution obtained from step b) is slowly added to said mother liquor allowing reaction to form salt until supersaturation is achieved while maintaining PH at a level securing that no unreacted acids remains after reaction, d) Crystals formed in the reaction of step c) is continuously or discontinuously removed from the reaction product of step c).

The present disclosure relates to crystalline forms of 4,5,6,7-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione, including salts forms and free base forms.

The present disclosure relates to crystalline forms of 4,5,6,7-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione, including salts forms and free base forms.

Provided is an EGFR inhibitor and a pharmaceutically acceptable salt and a polymorph thereof, and a use thereof. In particular, provided is a polymorph, a pharmaceutically acceptable salt or a prodrug of N-(2-(4-(dimethylamino)piperid-1-yl)-5-(5-fluoro-4-(1-methyl-1H-pyrazol-4-yl) pyrimidin-2-ylamino)-4-methoxy phenyl) acrylamide. In addition, also provided is a pharmaceutical composition containing the inhibitor and a use thereof.

A process for the production of glycolic acid or derivatives thereof from formaldehyde comprising reacting formaldehyde with carbon monoxide and water in the presence of a silica catalyst, wherein from about 200 to about 5000 ppm of an alkyl silyl sulfonic acid is supplied to the reaction.

A process for the production of glycolic acid or derivatives thereof from formaldehyde comprising reacting formaldehyde with carbon monoxide and water in the presence of a silica catalyst, wherein from about 200 to about 5000 ppm of an alkyl silyl sulfonic acid is supplied to the reaction.

Provided are a lignin degradation catalyst that exhibits excellent lignin degradability and that is readily separated after degradation reaction, a method for producing the catalyst, and a method for degrading lignin. The lignin degradation catalyst according to the present invention contains a substrate and at least one metal compound immobilized on the substrate, wherein the at least one metal compound contains a copper compound. The method for producing a lignin degradation catalyst according to the present invention includes the step of brining a porous copper substrate into contact with a solution containing an oxidant to obtain a substrate having a copper compound immobilized thereon, or the step of subjecting a porous copper substrate to electro-oxidation to obtain a substrate having a copper compound immobilized thereon.

Provided are a lignin degradation catalyst that exhibits excellent lignin degradability and that is readily separated after degradation reaction, a method for producing the catalyst, and a method for degrading lignin. The lignin degradation catalyst according to the present invention contains a substrate and at least one metal compound immobilized on the substrate, wherein the at least one metal compound contains a copper compound. The method for producing a lignin degradation catalyst according to the present invention includes the step of brining a porous copper substrate into contact with a solution containing an oxidant to obtain a substrate having a copper compound immobilized thereon, or the step of subjecting a porous copper substrate to electro-oxidation to obtain a substrate having a copper compound immobilized thereon.

Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state:

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Also provided are processes of manufacture and methods of using the crystalline forms.