Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

The present disclosure relates to free base and salt crystals of 2-(4-acetylbenzyl)-3-((4-fluorophenyl)amino)-5,7,7-trimethyl-7,8-dihydro-2H-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one, composition comprising the same and the method of making and using such free base and salt crystals.

A method for producing glycolic acid includes selectively hydrogenating glyoxylic acid using a catalyst comprising at least one transition metal element, the glycolic acid produced, which has a bio-based carbon content of above 50%. A method for preparing a composition selected from the group consisting of cosmetics, home care products, personal care products, textiles, food, beverages, drugs, fragrances, inks, or paints includes adding the glycolic acid to the composition.

A method for producing glycolic acid includes selectively hydrogenating glyoxylic acid using a catalyst comprising at least one transition metal element, the glycolic acid produced, which has a bio-based carbon content of above 50%. A method for preparing a composition selected from the group consisting of cosmetics, home care products, personal care products, textiles, food, beverages, drugs, fragrances, inks, or paints includes adding the glycolic acid to the composition.

A method for producing glycolic acid includes selectively hydrogenating glyoxylic acid using a catalyst comprising at least one transition metal element, the glycolic acid produced, which has a bio-based carbon content of above 50%. A method for preparing a composition selected from the group consisting of cosmetics, home care products, personal care products, textiles, food, beverages, drugs, fragrances, inks, or paints includes adding the glycolic acid to the composition.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

The present invention refers to a catalytic system comprising a transition metal compound on a solid carrier, wherein the content of the transition metal element on the surface of the solid carrier is from 0.1 to 30 wt.-%, based on the dry weight of the solid carrier. Furthermore, the present invention refers to a method for manufacturing the catalytic system, the use of the inventive catalytic system in a chemical reaction, the use of a solid carrier loaded with a transition metal as a catalyst and to granules mouldings or extrudates comprising the catalytic system.

The present invention refers to a catalytic system comprising a transition metal compound on a solid carrier, wherein the content of the transition metal element on the surface of the solid carrier is from 0.1 to 30 wt.-%, based on the dry weight of the solid carrier. Furthermore, the present invention refers to a method for manufacturing the catalytic system, the use of the inventive catalytic system in a chemical reaction, the use of a solid carrier loaded with a transition metal as a catalyst and to granules mouldings or extrudates comprising the catalytic system.