Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.

Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.

A benzodiazepine compound represented by formula I, or a salt thereof has an intravenous sedative anesthesia effect. The recovery quality of the compound is significantly improved compared with remimazolam in rat and mouse caudal venous anesthesia models. During anesthetization, the compound has a rapid onset, a short duration, a quick recovery and a good tolerance, can be used for anesthesia induction, anesthesia maintenance and day surgery anesthesia.

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Provided is a process for producing acrylic acid, the process including supplying a lactic acid raw material to an upper portion of a distillation tower; supplying water to a lower portion of the distillation tower; supplying a first lactic acid vapor vaporized in the distillation tower to a reactor; and supplying a second aqueous lactic acid solution not vaporized in the distillation tower to a middle portion of the distillation tower. The process uses a distillation tower instead of a vaporizer, and is capable of preventing formation of a lactic acid oligomer during vaporization of an aqueous lactic acid solution, and, by introducing a concentrated lactic acid raw material to the distillation tower as it is, is capable of producing acrylic acid without a separate dilution device.

Provided is a process for producing acrylic acid, the process including supplying a lactic acid raw material to an upper portion of a distillation tower; supplying water to a lower portion of the distillation tower; supplying a first lactic acid vapor vaporized in the distillation tower to a reactor; and supplying a second aqueous lactic acid solution not vaporized in the distillation tower to a middle portion of the distillation tower. The process uses a distillation tower instead of a vaporizer, and is capable of preventing formation of a lactic acid oligomer during vaporization of an aqueous lactic acid solution, and, by introducing a concentrated lactic acid raw material to the distillation tower as it is, is capable of producing acrylic acid without a separate dilution device.

The disclosure relates to oral formulations for gastric delivery of a pharmaceutically acceptable salt of a phenyl pyrrole aminoguanidine compound.

Industrial fermentation for the production of lactic acid from organic waste combined with chemical recycling of polylactic acid are provided, to obtain lactic acid at high yields.

Industrial fermentation for the production of lactic acid from organic waste combined with chemical recycling of polylactic acid are provided, to obtain lactic acid at high yields.

The present invention relates to a novel liquid-liquid extraction process of a bio-oil obtained by an improved thermochemical process. This extraction process gives rise to two distinct phases: an organic phase, with bio-oil of energetic added value, and an aqueous phase, where the following can be obtained by chemical compounds with added value: lactic acid, formic acid, hydroxymethylfurfural, furfural, levulinic acid, monosaccharides, disaccharides and compounds with antioxidant properties, among others.

The present invention relates to a novel liquid-liquid extraction process of a bio-oil obtained by an improved thermochemical process. This extraction process gives rise to two distinct phases: an organic phase, with bio-oil of energetic added value, and an aqueous phase, where the following can be obtained by chemical compounds with added value: lactic acid, formic acid, hydroxymethylfurfural, furfural, levulinic acid, monosaccharides, disaccharides and compounds with antioxidant properties, among others.