A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

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A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

##STR00001##

The present disclosure relates to the use of a multicarboxylate, such as an alkyl alkoxy dicarboxylate, in enhanced oil recovery processes. Embodiments relate to an aqueous stream and the use thereof. The aqueous stream includes a compound having the chemical formula: R.sub.1-R.sub.2-R.sub.3, wherein R.sub.1 includes a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having an oxygen atom linking R.sub.1 and R.sub.2; R.sub.2 includes an alkoxylated chain comprising ethylene oxide, propylene oxide, butylene oxide, or a combination thereof; and R.sub.3 includes a branched or unbranched hydrocarbon chain and 2-5 COOH or COOM groups wherein M is a monovalent, divalent, or trivalent cation. R.sub.3 includes 2-12 carbon atoms.

The present disclosure relates to the use of a multicarboxylate, such as an alkyl alkoxy dicarboxylate, in enhanced oil recovery processes. Embodiments relate to an aqueous stream and the use thereof. The aqueous stream includes a compound having the chemical formula: R.sub.1-R.sub.2-R.sub.3, wherein R.sub.1 includes a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having an oxygen atom linking R.sub.1 and R.sub.2; R.sub.2 includes an alkoxylated chain comprising ethylene oxide, propylene oxide, butylene oxide, or a combination thereof; and R.sub.3 includes a branched or unbranched hydrocarbon chain and 2-5 COOH or COOM groups wherein M is a monovalent, divalent, or trivalent cation. R.sub.3 includes 2-12 carbon atoms.

The present disclosure relates to the use of a multicarboxylate, such as an alkyl alkoxy dicarboxylate, in enhanced oil recovery processes. A specific embodiment relates to the use of an aqueous stream including a compound having the chemical formula: R.sub.1R.sub.2R.sub.3, wherein R.sub.1 comprises a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having 7-150 carbon atoms; an oxygen atom linking R.sub.1 and R.sub.2; R.sub.2 comprises an alkoxylated chain comprising ethylene oxide, propylene oxide, butylene oxide, or a combination thereof; and R.sub.3 comprises a branched or unbranched hydrocarbon chain comprising 2-12 carbon atoms and 2-5 COOH or COOM groups wherein M is a monovalent, divalent, or trivalent cation.

The present disclosure relates to the use of a multicarboxylate, such as an alkyl alkoxy dicarboxylate, in enhanced oil recovery processes. A specific embodiment relates to the use of an aqueous stream including a compound having the chemical formula: R.sub.1R.sub.2R.sub.3, wherein R.sub.1 comprises a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having 7-150 carbon atoms; an oxygen atom linking R.sub.1 and R.sub.2; R.sub.2 comprises an alkoxylated chain comprising ethylene oxide, propylene oxide, butylene oxide, or a combination thereof; and R.sub.3 comprises a branched or unbranched hydrocarbon chain comprising 2-12 carbon atoms and 2-5 COOH or COOM groups wherein M is a monovalent, divalent, or trivalent cation.

The present disclosure relates to the use of a multicarboxylate, such as an alkyl alkoxy dicarboxylate, in enhanced oil recovery processes. Embodiments relate to an aqueous stream and the use thereof. The aqueous stream includes a compound having the chemical formula: R.sub.1R.sub.2R.sub.3, wherein R.sub.1 includes a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having an oxygen atom linking R.sub.1 and R.sub.2; R.sub.2 includes an alkoxylated chain comprising ethylene oxide, propylene oxide, butylene oxide, or a combination thereof; and R.sub.3 includes a branched or unbranched hydrocarbon chain and 2-5 COOH or COOM groups wherein M is a monovalent, divalent, or trivalent cation. R.sub.3 includes 2-12 carbon atoms.

The present disclosure relates to the use of a multicarboxylate, such as an alkyl alkoxy dicarboxylate, in enhanced oil recovery processes. Embodiments relate to an aqueous stream and the use thereof. The aqueous stream includes a compound having the chemical formula: R.sub.1R.sub.2R.sub.3, wherein R.sub.1 includes a branched or unbranched, saturated or unsaturated, cyclic or non-cyclic, hydrophobic carbon chain having an oxygen atom linking R.sub.1 and R.sub.2; R.sub.2 includes an alkoxylated chain comprising ethylene oxide, propylene oxide, butylene oxide, or a combination thereof; and R.sub.3 includes a branched or unbranched hydrocarbon chain and 2-5 COOH or COOM groups wherein M is a monovalent, divalent, or trivalent cation. R.sub.3 includes 2-12 carbon atoms.

This present invention provides gemcabene pharmaceutically acceptable salts having a PSD90 of 35 m to about 90 m, methods for purifying crude gemcabene, pharmaceutically acceptable salts of purified gemcabene, pharmaceutical compositions of a gemcabene pharmaceutically acceptable salt and therapeutic and prophylactic methods useful for various conditions, including dyslipidemia.

This present invention provides gemcabene pharmaceutically acceptable salts having a PSD90 of 35 m to about 90 m, methods for purifying crude gemcabene, pharmaceutically acceptable salts of purified gemcabene, pharmaceutical compositions of a gemcabene pharmaceutically acceptable salt and therapeutic and prophylactic methods useful for various conditions, including dyslipidemia.