The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof. ##STR00001##

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof. ##STR00001##

A resist composition comprising a base polymer and a quencher containing a sulfonium salt having an iodized benzene ring offers a high sensitivity, minimal LWR and improved CDU independent of whether it is of positive or negative tone.

A resist composition comprising a base polymer and a quencher containing a sulfonium salt having an iodized benzene ring offers a high sensitivity, minimal LWR and improved CDU independent of whether it is of positive or negative tone.

Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof.

##STR00001##

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof.

##STR00001##

The present invention discloses 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(-hydroxypentyl)benzoic acid potassium salt.

The present invention discloses 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(-hydroxypentyl)benzoic acid potassium salt.